Senior Director, IT

At Nautilus, we have a big and important mission: improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single-molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome – one of the most dynamic and valuable sources of biological insight. To accomplish this, we are pursuing hard scientific problems with an entrepreneurial mindset and creating a world-class team of builders, innovators, and dreamers across a wide range of disciplines. As the Senior Director of IT , you will drive the technological vision of our company, ensuring our systems are scalable, secure, and innovative. This role requires a forward-thinking leader who thrives in a fast-paced environment, can plan strategically, work tactically, and be hands-on in implementation. This position will report to the Senior Director of Software Engineering and IT, and will be located in San Carlos, CA. Responsibilities Develop and implement IT strategies that align with organizational goals. Combine strategic leadership with practical, day-to-day technical engagement to drive reliable operations across infrastructure, hardware, networking, systems management, ensuring reliability, scalability, and performance. Ensure data security, compliance, incidence response and disaster recovery protocols are in place. Oversee and own IT budgets, vendor relationships, and procurement processes to ensure cost-effective and value-driven technology investments. Provide regular updates to senior leadership on IT budget performance, risk posture, cybersecurity initiatives, and strategic priorities. Identify and implement emerging technologies to improve business processes. Implement AI strategy for increased organizational efficiency, decision-making, and operational outcomes. Collaborate with software, operations, and legal teams to define and enforce enterprise-wide data governance policies and practices. Partner with engineering, operations, finance, and software teams to enable technology-driven commercialization efforts Drive the selection, integration and management of business systems (ERP, HRIS, PLM, CRM, etc.) crucial to operations and commercialization efforts. Play an integral role in product definition, requirements specification and execution Champion DevOps practices driving infrastructure-as-code (IaC), automation, continuous integration and continuous delivery (CI/CD) pipelines. Inspire, mentor, and grow high-performing IT teams, fostering a culture of innovation, accountability, and cross-functional collaboration. Set and communicate clear team priorities, ensuring alignment with company strategy and responsiveness to evolving business needs. Build and reinforce scalable, actionable processes that empower teams to make informed decisions and deliver consistent results. Foster collaboration between development and operations teams to streamline deployment processes and improve system reliability. Navigate and lead teams through change, leveraging competitive insights and innovative thinking to adapt and thrive in dynamic environments. Qualifications Bachelor’s degree in information technology, information systems, computer science or a related field. 12+ years of IT experience, with 10+ years in a managerial role. Expertise in cloud computing (preferably AWS and Azure), network design and infrastructure, and enterprise software. Experience managing DevOps, driving IaC, automation, CI/CD pipelines, and collaboration between development and operations teams. Experience deploying security and SaaS tools across organizations. Proven experience deploying commercial products. Deep understanding of IT architecture and cybersecurity. Strong familiarity with software development practices. Strong leadership and project management skills. Experience with regulatory standards across data privacy, security, financial data management (GDPR, CCPA, HIPAA, SOX, ISO27001, etc.). Requires bimonthly travel between office locations. Nautilus Team Culture We are curious go-getters: this is a team of life-long learners who aren’t afraid to tackle the big challenges, and we embrace the journey. We are detail-oriented: we do great science by working smart & with diligence where we learn from our trials and mistakes. We are easy to work with: we want our workplace to be one where everyone can share their perspective and be treated with respect and kindness. #LI-MM1