Sr. Advisor, Molecular Pharmacology

Centessa Pharmaceuticals, a wholly owned subsidiary of Eli Lilly and Company, is a clinical-stage company developing orexin receptor 2 (OX2R) agonists as a new class of medicines for the treatment of narcolepsy and potentially other sleep-wake disorders. Centessa’s lead investigational candidate – cleminorexton (formerly ORX750) – is being developed for narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia. Centessa's OX2R agonist portfolio includes additional clinical and preclinical-stage assets with potential utility across a broader range of neurological, neurodegenerative, and neuropsychiatric conditions. Headquartered in Boston, Massachusetts, Centessa was recognized as a Great Place to Work ® in 2026. Description of Role We are seeking a Sr. Advisor, Molecular Pharmacology to serve as a senior scientific contributor within the team, reporting to the Head of Molecular Pharmacology. This is an Associate Director level position that will provide deep technical expertise in molecular pharmacology and in vitro translational neuroscience, with a particular focus on functional and affinity modulation assays as well as brain slice electrophysiology, to strengthen mechanistic understanding across discovery programs. While all experimental work is conducted through external partners, this individual will play a central role in study design, CRO management, data interpretation, and translation of functional data into program strategy. Key Responsibilities Serve as the Molecular Pharmacology team’s subject-matter expert in neuroscience pharmacology, guiding in vitro and ex vivo assay selection, study design, and translational interpretation of results. Own the scientific strategy and design of in vitro and ex vivo pharmacology studies, with emphasis on brain slice electrophysiology and circuit-level functional assays executed at CROs. Manage external CROs, including protocol development, technical alignment, data review, and troubleshooting to ensure high-quality, fit-for-purpose studies. Partner closely with the Director of Molecular Pharmacology and cross-functional colleagues (chemistry, biology, translational, in vivo) to interpret results and inform program decisions. Contribute to broader scientific discussions around program direction, helping refine hypotheses and deepen biological understanding. Provide scientific guidance and review to junior team members (no direct people management responsibilities). Qualifications PhD in Neuroscience, Pharmacology, Physiology, or a related field. 6+ years of relevant postdoctoral or industry experience (or MS/BS with commensurate industry experience). Demonstrated experience with in vitro functional and affinity modulation of GPCR targets in a drug discovery setting, as well as expertise in brain slice electrophysiology and related circuit-level approaches (eg, MEA experience highly desired), including study design, CRO oversight, and data interpretation to support decision-making in drug development programs Strong foundation in molecular and cellular pharmacology. Experience working with CROs and external research partners. Proven ability to connect mechanistic data to in vivo relevance and program decision-making. Highly collaborative, scientifically rigorous, and comfortable operating in a matrixed environment. Work Location The Senior Advisor, Molecular Pharmacology role is a remote role based in the US, with occasional travel. Compensation The annual base salary range for this position is $140,000.00 to $215,000.00. Individual compensation within this range will be determined based on a variety of factors, including qualifications, skills, relevant experience, job knowledge an location. In addition to base pay, this role is eligible for a discretionary annual bonus. The Company also offers a comprehensive benefits package, which includes a 401(k) plan, company-sponsored medical, dental, vision, and life insurance, generous paid time off, and a health and wellness program. POSITION: Full-Time, Exempt EEOC Statement: Centessa Pharmaceuticals, a wholly owned subdisary of Eli Lilly and Company believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion, or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. We will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Please note: We will not assign referral rights for any unsolicited resumes from recruitment agencies.