Vice President, Head of Data Science & Biostatistics

Salary Range: $288,275.00 To $377,128.00 Annually Vice President, Head of Data Science & Biostatistics – Solid Biosciences Solid Biosciences is a precision genetic medicine company focused on advancing a portfolio of gene therapy candidates targeting rare neuromuscular and cardiac diseases, including Duchenne muscular dystrophy (Duchenne), Friedreich’s ataxia (FA), catecholaminergic polymorphic ventricular tachycardia (CPVT), TNNT2-mediated dilated cardiomyopathy, BAG3-mediated dilated cardiomyopathy, and additional fatal, genetic cardiac diseases. We are advancing a diverse pipeline and delivery platform in the pursuit of uniting experts in science, technology, disease management, and care. Patient-focused and founded by those directly impacted by Duchenne, Solid’s mission is to improve the daily lives of patients living with devastating rare diseases. We are seeking a Vice President, Head of Data Science & Biostatistics to provide strategic and operational leadership for data sciences across late-stage clinical development for multiple Phase 3 gene trials as well as early stage clinical studies focused on neuromuscular and cardiac diseases. This role will partner cross-functionally to ensure the integrity, rigor, and translational value of clinical data, enabling decisive regulatory, clinical, and commercial outcomes. This leader will oversee a team of biostatisticians and serve as the accountable executive for statistical strategy, data science innovation, and biostatistics integration across clinical programs. The VP will play a critical role in advancing registrational studies, regulatory filings, and lifecycle management while building scalable capabilities to support commercialization and post-marketing evidence generation. Reporting to the Chief Medical Officer, the role will be flexible based on location and alignment with the CMO. Key Position Responsibilities Define and execute the company’s data science, biostatistics, and biostatistics strategy aligned to Phase 3 execution and regulatory success. Serve as a core member of the Clinical Leadership Team and partner with the CMO on clinical strategy. Lead statistical design and execution of Phase 3 trials, including SAPs, protocols, and interim analyses. Ensure compliance with GCP, ICH guidelines, and regulatory expectations. Support regulatory submissions (BLA/MAA) and health authority interactions. Integrate biost and multi-omics data into clinical development. Advance modern data science approaches, including modeling and AI/ML where appropriate. Lead and develop a team of 4 biostatisticians. Lead and develop a team of 3 database managers Manage CROs and external partners. Partner cross-functionally across Clinical, Regulatory, Medical Affairs, and Commercial. Experience Requirements Master’s degree of higher in Biostatistics, Statistics, or related field. 15+ years in biotech/pharma with late-stage clinical experience. Proven success supporting regulatory submissions and FDA/EMA interactions. Experience in gene therapy, rare disease, or neuromuscular/cardiac indications preferred. Expertise in clinical trial design, statistical methods, and regulatory standards. Strong leadership and communication skills. Key Position Attributes Strategic Judgment with Clinical Impact: Translates complex data into clear, decision-ready insights and anticipates risks in trial design, endpoints, and data interpretation. Balances scientific rigor with speed in a late-stage environment. Executive Communication & Influence: Distills statistical complexity into concise messaging for the CMO, ELT, and Board; effectively represents the company with regulators and external stakeholders. Ownership & Accountability: Operates as the single point of accountability for statistical strategy and data integrity; drives critical milestones with urgency and accountability. Hands-On Leadership in a Lean Environment: Functions as a player-coach, willing to engage deeply in technical work while leading a small, high-impact team and prioritizing effectively. Talent Development & Team Leadership: Builds, mentors, and retains a high-performing team of biostatisticians; elevates technical rigor, communication, and execution standards. Cross-Functional Integration: Seamlessly integrates clinical, biostatistics, and translational data; aligns stakeholders across Clinical, Regulatory, and Technical functions. Compensation The base compensation range for this role is: $288,275 - $377,128. Base salary offered is determined through an internal analysis utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity. Regular employees are eligible to receive both short-term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward individual performance and align incentives to Solid’s long term company performance. Benefits and Solid Advantages At Solid Biosciences we offer a highly competitive total rewards and benefits package, intended to support all aspects of our employees’ lives and well-being. Additionally, for those employees working onsite at our Hood Park Headquarters, we offer a variety of onsite resources to support those working in our offices. Competitive Health and Dental programs with flexible plan offerings, including FSA and HSA programs 401(k) program participation with competitive company matched contributions Eligibility to participate in Solid’s Employee Stock Purchase Plan Mobile phone subsidy for eligible employees Tuition Reimbursement Vision Coverage Life Insurance Voluntary Pet Insurance Employee Discount Program on Travel, Entertainment, and Services Daily Subsidized Lunch Delivery (onsite @ Hood Park) Free Onsite Full-Service Gym (onsite @ Hood Park) Employee Parking (onsite @ Hood Park)