Senior Scientist, Pharmacology

Janux Therapeutics is seeking a scientifically curious and motivated Senior Scientist with demonstrated abilities to work in a fast-paced environment. The incumbent will design, develop and execute in vitro assays for compound characterization using multicolor flow cytometry, cell-based functional assay, MSD, Octet, and other relevant technologies, as well as develop murine models for efficacy evaluation and mechanism-of-action (MoA) investigations. This position is hands-on and requires strong experimental execution, data interpretation, communication, CRO management and documentation of results that enable the advancement of novel research molecules toward development candidates. Strong candidates will be creative, collaborative, and passionate about drug discovery and development. Expertise in tumor biology, immunology and pharmacology is required. As a strategic team member, you will directly support decision-making for pipeline programs as they progress from early Research through IND-enabling studies, IND submission and clinical development. This position will report directly to the Senior Director of Pharmacology. ESSENTIAL FUNCTIONS AND RESPONSIBILITIES Identify, develop and execute multicolor flow cytometry panels, in vitro functional assays, and in vivo pharmacology studies independently to support both in vivo and in vitro pharmacology programs. Independently design and execute assays, including assay development, optimization, qualification (when required), sample analysis, data analysis, and preparation of study report and SOPs. Develop and implement murine modeo support target and MoA validation. Analyze and present experimental data using Prism, Excel, MS Office or similar software, and present findings to cross-functional groups. Maintain detailed records of studies in electronic lab notebook (ELNs). Keep up to date with published literature related to therapeutic targets, disease biology, and mechanisms relevant to Janux programs. Train and support junior team members to design, manage and execute complex experimental studies. Produce detailed documentation of experiments within a lab notebook and electronically. Collaborate effectively with cross-functional teams and external CROs to ensure successful study execution and delivery of project milestones. Ability to schedule and prioritize workload effectively within a multi-task environment. Other duties as deemed necessary. EDUCATION, EXPERIENCE, KNOWLEDGE, SKILLS AND ABILITIES Ph.D. in Immunology, Cell Biology, Biotechnology, Pharmacology or a related discipline with at least 3 years of drug discovery experience, MS+ 10 years of drug discovery experience, or BS+ 12 years of drug discovery experience in an industry setting is required. Strong expertise and hands-on experience with multicolor flow cytometry panel development, cell-based functional assay is required. Experience with assay qualification and validation, including flow cytometry panel and bioanalytical assay (PK, ADA and Nab), is preferred. Strong understanding and prior experience working in oncology, immunology, and immune-oncology, with hands on experience in murine model development and associated sample analysis, is required. Experience working with external CROs (due diligence, oversight, project management, data review, and reporting) is desirable. Competence in data analysis tools (Excel, GraphPad). Strong analytical and critical thinking skills with the ability to work in a fast-paced environment. Strong analytical skills and ability to work in a highly collaborative environment. Excellent written, oral, and presentation communication skills. Demonstrated ability to manage multiple priorities and deliver high-quality results in a fast-pace environment. Job Type: Full-time Benefits: · Annual bonus program · Incentive stock option plan · 401k plan with flat non-elective employer contribution · Comprehensive medical insurance with 90-100% employer-paid premiums · Dental and vision insurance · HSA, FSA, and supplemental insurance plans (life, disability, accident, critical illness, hospital indemnity) · Unlimited PTO · Generous holiday schedule; includes summer and winter company shutdown · Relocation assistance Schedule: · Monday to Friday Work authorization: · United States (Required) Additional Compensation: · Annual targeted bonus % Work Location: · On site (San Diego, CA) EQUAL OPPORTUNITY EMPLOYER: Janux Therapeutics, Inc. is an equal opportunity employer that is committed to providing a work environment free of harassment and discrimination based upon a protected category, as well as an environment free from retaliation for protected activity. Notice to Recruiters and Third-Party Agencies The Talent Acquisition team manages the recruitment and employment process for Janux. To protect the interests of all parties involved, Janux will only accept resumes from a recruiter once a fully-executed search agreement is in place. Agencies are hereby specifically directed not to contact Janux employees directly in an attempt to present candidates. Janux will consider any candidate for whom an Agency and/or Recruiter has submitted an unsolicited resume to have been referred, free of any charges or fees.