Lab Research Analyst II

School of Medicine:

Established in 1930, Duke University School of Medicine is the youngest of the nation's top medical schools. Ranked sixth among medical schools in the nation, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where interdisciplinary collaboration is embraced and great ideas accelerate translation of fundamental scientific discoveries to improve human health locally and around the globe. Composed of more than 2,600 faculty physicians and researchers, nearly 2,000 students, and more than 6,200 staff, the Duke University School of Medicine along with the Duke University School of Nursing, and Duke University Health System comprise Duke Health, a world-class academic medical center. The Health System encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Health Integrated Practice, Duke Primary Care, Duke Home Care and Hospice, Duke Health and Wellness, and multiple affiliations.

Be You.

The Department of Neurobiology at Duke University is seeking a Lab Research Analyst II to join our research team. In this role, you will work on research projects involving bioinformatics analysis of single-cell genomics and spatial transcriptomics data with the aim to improve the understanding of the development and function of specific neural cell types and neural circuits.

You will contribute to projects focused on developing and applying new tools to trace and modulate specific circuits with single-cell and cell type-specific resolution. The position will involve bioinformatics analysis of single-cell genomics (including 10x Genomics and single-cell HiCAR) and spatial transcriptomics data (Open-ST), as well as integrating them with barcoded rabies virus tracing and labeling data. This position also provides opportunities to develop innovative bioinformatics methods to analyze sequencing-based spatial transcriptomics and barcoded viral tracing data. These efforts are expected to result in high-quality peer-reviewed journals.

Minimum Requirements

• Generally requires a bachelor’s degree in computer science, bioinformatics, biostatistics or related biomedical discipline. Master’s degree is preferred.
• Work requires four years of research experience. A related master's degree may offset required years of experience on a 1:1 basis, e.g., a two year master's degree in lieu of two years of experience. OR AN EQUIVALENT COMBINATION OF RELEVANT EDUCATION AND/OR EXPERIENCE
• Solid training in bioinformatics methods.
• Experience analyzing single-cell genomics data.
• Strong programming skills in R and python.
• Proficiency working within UNIX/Linux environments.
• Excellent written and verbal communication skills.

Preferred Qualifications

• Experience with developing novel bioinformatics methods and pipelines.
• Experience with single-cell multiome data analysis.
• Experience with analyzing spatial transcriptomics data.
• Knowledge of machine learning methods.

Other Requirements

Application materials must include:

• Curriculum Vitae (CV)
• Statement of research interests
• Names of three professional references

Work Arrangement

• Hybrid. First month is expected to be on-site for integration and training purposes. After that, minimum 3 days on-site and 2 days optional remote. Different arrangement is possible via agreement with the PI. The on-site work is performed at Duke University in Durham, North Carolina.

Appointment Term

• Initial appointment is for one year.
• Renewal may be considered based on project needs and available funding.

Be Bold.

Key Responsibilities:

• Analyze single-cell genomics and spatial transcriptomics data for various cutting-edge projects aimed at dissecting the molecular mechanisms of brain development.
• Develop and apply novel tools to perform integrative analysis of spatial transcriptomics and single-cell genomics data from neurons labeled barcoded rabies virus (mRNA+viral barcode analysis).
• Develop and apply novel tools to analyze joint trimodal single-cell HiCAR data (RNA expression+chromatin accessibility+3D genome organization).
• Develop and apply novel tools to analyze multiplexed CRISPR screen single-cell genomics data.
• Contribute to the preparation and publication of research findings in peer-reviewed journals.

Choose Duke.

Duke University is consistently recognized among the top research institutions in the United States and around the world. Located in Durham, North Carolina, Duke offers a collaborative academic environment where researchers work across disciplines to address important challenges in healthcare and science.

As a Postdoctoral Associate in the Department of Biostatistics and Bioinformatics, you will have the opportunity to work with leading investigators, contribute to impactful cancer research, and advance innovative statistical methodologies while building a strong publication record.

Job Code: 00001215 LAB RESEARCH ANALYST II

Job Level: 71

Anticipated Pay Range: Duke University provides an annual base salary range for this position as USD $61,026.00 to USD $98,439.00. Duke University considers factors such as (but not limited to) scope and responsibilities of the position; candidate's work experience, education/training, and key skills; internal peer equity; as well as market and organizational considerations when extending an offer.

Your total compensation goes beyond the dollars on your paycheck. Duke provides comprehensive and competitive medical and dental care programs, generous retirement benefits, and a wide array of family-friendly and cultural programs to eligible team members. Learn more at: https://hr.duke.edu/benefits/

Equal Opportunity Employer: Duke is an Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex (including pregnancy and pregnancy- related conditions), sexual orientation, or military status.

Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.

Essential Physical Job Functions:

Certain jobs at Duke University and Duke University Health System may include essential job functions that require specific physical and/or mental abilities. Additional information and reasonable accommodation(s) can be requested with Duke Access and Accommodations Services (email: DAAS@duke.edu; phone: 919-668-1267).