Principal Engineer

Company Information Clinical Ink is the global life science company that brings data, technology, and patient science together to unlock clinical discovery. Our deep therapeutic-area expertise, coupled with Direct Data Capture, eCOA, eConsent, telehealth, neurocognitive testing, and digital biomarkers advancement, drive the industry standard for data precision and usher in a new generation of clinical trials. With offices in the United States and Denmark, Clinical Ink is rewriting the clinical development experience. Job Description Clinical Ink is seeking a Principal Engineer to to join Clinical Ink's Disease Management team based in Denmark and the United States. As Principal Engineer you are the most senior individual contributor on the platform. You set technical direction and own the architecture across repos and services — not one team’s corner of it — including how it runs in production. You author the contracts (intended use → requirements → design → tests) that downstream engineers and CI controls trace against, own the infrastructure, reliability, and observability backbone, make the cross-cutting decisions, and remain hands-on enough that your judgment is grounded in the code. You’re a force-multiplier: the team moves faster, more safely, and more reliably because of the structure you put in place. The Principal Engineer's responsibilities include but are not limited to: Own the backend and platform architecture: service boundaries, the modular/domain-aligned design, data flow, tenant isolation, and the public API surface the mobile app and integrations depend on. Author and steward architecture and design records — intended-use statements, system/software requirements, ADRs — and keep them traceable through to verification. Make the architecture legible to everyone who builds on it. Own the infrastructure and production-reliability backbone: infrastructure-as-code (Terraform), the AWS runtime (ECS Fargate, RDS), CI/CD pipelines, and the security posture (secrets, IAM, least-privilege, HIPAA controls). Set the observability and operability bar: SLOs/SLIs and error budgets; metrics, traces, and logs (CloudWatch, Sentry, OpenTelemetry); actionable alerting; and a humane, well-designed on-call. Design systems to be operated, not just shipped. Drive the build-vs-buy and significant-change decisions, and weigh each against phase impact (consumer → sponsor trials → SaMD). Set the bar for correctness and safety as design inputs: scoring parity across implementations, idempotency and retries in integrations, encryption and least-privilege, and the controls that prove the code is right. Go deep where it matters — design and build the hardest backend pieces yourself (services, data contracts, third-party adapters), and review the rest. Multiply the team with AI-augmented workflows: design the agentic patterns, skills, and guardrails the team uses to build faster without lowering the bar. Partner with the Director and regulatory/clinical stakeholders to turn product and compliance intent into a buildable, defensible technical plan. Qualifications Deep backend engineering experience (we use Python / FastAPI / SQLAlchemy / Postgres on AWS; equivalent depth in another modern stack transfers) and a track record of owning architecture for a non-trivial system. Demonstrated ability to design distributed/service systems: API design, data modeling, async/eventing, integration patterns (OAuth, webhooks, retries, idempotency). Owned production reliability for a real system — you’ve designed for observability, set SLOs, carried a pager, and made infrastructure/IaC calls (Terraform / AWS or equivalent). You treat “how it runs and how we know” as part of the architecture. A genuine drive to build and ship — you bias toward working software and measurable impact, and you bring others with you. Fluency with AI coding agents as part of how you work, plus the judgment to verify and own what they produce. Clear technical writing — you make complex systems understandable to engineers, clinicians, and executives alike. Health / regulated / safety-critical software (SaMD, IEC 62304, ISO 14971, HIPAA, FDA pathways). Healthcare data and interoperability (FHIR, wearables — Withings / Polar / Whoop / Fitbit, Apple Health / Health Connect). Data/analytics at scale (Snowflake, dbt, de-identification pipelines). Mobile-adjacent experience (Flutter) or on-device scoring. Additional Information Clinical Ink is an equal opportunity employer and does not discriminate against otherwise qualified applicants on the basis of race, color, creed, religion, ancestry, age, sex, marital status, national origin, disability or handicap, or veteran status. www.clinicalink.com