Remote | Clinician (Oncology / Hematology) — $160–$200/hour

We are sharing a specialised consulting opportunity for experienced oncology and haematology clinicians with strong expertise in clinical-trial evaluation, safety and efficacy assessment, CTCAE grading, disease-specific response criteria, benefit-risk analysis, medical monitoring, and regulatory clinical documentation to contribute to an advanced AI training and healthcare evaluation project.

Selected professionals will author and review complex clinical evaluation tasks, assess the defensibility of oncology and haematology conclusions, evaluate efficacy and safety endpoints, and provide structured written rationales grounded in clinical guidelines and trial evidence. The work requires advanced clinical judgement, familiarity with regulatory trial documentation, and the ability to explain nuanced medical reasoning clearly to non-clinical audiences. No prior experience in AI is required.

Key Responsibilities

Clinical Trial Evaluation

• Author and review evaluation tasks requiring nuanced oncology and haematology judgement
• Analyse Clinical Study Reports, periodic safety reports, and regulatory correspondence
• Evaluate the clinical coherence of trial findings and interpretations
• Assess whether conclusions are adequately supported by available evidence
• Identify inconsistencies, missing context, or clinically implausible interpretations

Efficacy & Endpoint Assessment

• Evaluate efficacy conclusions across oncology and haematology trials
• Assess endpoints including ORR, DoR, PFS, OS, and MRD
• Determine whether observed effect sizes reflect meaningful clinical benefit
• Review endpoint interpretation for consistency with study design and disease context
• Distinguish statistical findings from clinically defensible conclusions

Response Criteria & Disease Assessment

• Apply RECIST criteria where appropriate
• Evaluate Lugano criteria for relevant lymphoma settings
• Apply IMWG criteria in plasma-cell disorders
• Assess IWCLL criteria in chronic lymphocytic leukaemia
• Apply ELN criteria in relevant haematologic malignancies
• Review disease-response classifications for accuracy and clinical consistency

Safety, Toxicity & Dose Evaluation

• Apply CTCAE grading to adverse events
• Assess attribution and clinical significance of safety findings
• Evaluate dose escalation and dose-limiting toxicity decisions
• Review dose modifications and treatment-management strategies
• Determine whether safety narratives and management approaches are clinically realistic

Benefit-Risk Analysis

• Evaluate benefit-risk reasoning across complex clinical scenarios
• Assess whether conclusions remain defensible in light of new safety or efficacy events
• Identify unsupported assumptions or overextended conclusions
• Review the durability of clinical interpretations over time
• Provide balanced analysis of therapeutic benefit and potential risk

Regulatory & Trial Document Review

• Review protocols, investigator brochures, Clinical Study Reports, and safety narratives
• Evaluate DSMB and IDMC materials where relevant
• Assess regulatory documents for clinical accuracy and internal consistency
• Identify discrepancies across different sources of clinical evidence
• Apply strong medical judgement to complex regulatory-trial documentation

Clinical Reasoning & Quality Evaluation

• Identify clinically implausible or internally inconsistent content
• Distinguish genuine errors from legitimate clinical variation
• Analyse ambiguous or borderline clinical interpretations
• Provide structured explanations of why conclusions are valid, limited, or unsupported
• Apply consistent guideline-based reasoning across evaluation tasks

Medical Monitoring & Committee-Level Review

• Contribute expertise informed by medical-monitoring or clinical-development experience
• Assess issues typically reviewed by medical monitors or medical directors
• Apply committee-level judgement to safety, efficacy, and adjudication questions
• Support evaluation of cases involving IDMC, DSMB, adjudication, or independent-review processes
• Review trial decisions from both patient-level and programme-level perspectives

Ideal Profile

• Specialist registration or board certification in medical oncology and/or haematology
• 5+ years of post-training clinical experience
• Direct experience as a clinical-trial investigator or sub-investigator, or in sponsor-side medical monitoring, safety, or clinical development
• Strong proficiency with CTCAE grading
• Familiarity with RECIST, Lugano, IMWG, IWCLL, and/or ELN criteria as relevant to clinical practice
• Strong understanding of oncology and haematology endpoints including ORR, DoR, PFS, OS, and MRD
• Experience evaluating dose escalation, dose-limiting toxicity, dose modification, and adverse-event attribution
• Hands-on experience reviewing protocols, investigator brochures, CSRs, safety narratives, or DSMB/IDMC materials
• Strong benefit-risk analysis and clinical-reasoning skills
• Excellent written communication ability
• Ability to explain complex clinical reasoning clearly to non-clinical audiences
• Previous medical-monitoring or oncology/haematology medical-director experience is highly valuable
• Experience participating in IDMC, DSMB, adjudication, or independent-review committees is advantageous
• Peer-reviewed publication experience or clinical-trial manuscript authorship is highly valued
• Exposure to AI-assisted clinical-review tools is beneficial but not required
• No prior AI-training or model-evaluation experience is required

Engagement Details

• Independent contractor engagement
• Fully remote
• Compensation: $160–$200/hour
• Work will involve oncology and haematology clinical-trial evaluation, efficacy and safety assessment, response criteria, CTCAE grading, endpoint analysis, benefit-risk review, regulatory-document evaluation, and structured clinical reasoning
• Strong clinical-trial and post-training oncology or haematology expertise is central to this engagement
• Assignments may involve CSRs, protocols, investigator brochures, safety narratives, DSMB/IDMC materials, regulatory correspondence, and patient-level clinical scenarios
• Structured written explanations for non-clinical audiences will form an important part of the work
• Project scope, workload, therapeutic areas, and evaluation standards may evolve depending on project requirements
• Work must be completed without using confidential, proprietary, or identifiable patient information belonging to any employer, sponsor, healthcare organisation, research institution, patient, or other third party

About the Platform

This opportunity is available through 24-MAG LLC. We connect experienced professionals with remote consulting opportunities across technical, evaluation, and project-based workstreams.

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