Senior Director, Financial Planning & Analysis - Commercial

Job Description

Vertex is growing at a rapid pace with exciting opportunities for motivated professionals who want to contribute to our mission to invest in scientific innovation to create transformative medicines for people with serious diseases. Our Finance function plays a critical role in delivering on this mission by shaping strategy, enabling informed decision making, and providing deep business insight to support value creation across the enterprise. 

General Role Summary:

The Senior Director of Commercial Finance is a senior leader within the US Commercial Finance organization and serves as the primary strategic business partner to the US Commercial Vice President and Business Unit Lead. This leader will partner with the BU Lead to develop options and guide resource allocation to balance growth and profitability.  This highly visible role leads a team responsible for strategic financial management, revenue forecasting, analytics, investment management, and value creation across the business. 

Key Duties and Responsibilities:

Strategic Leadership & Business Partnership

• Serve as the finance business partner to the US Commercial Vice President and Business Unit Lead, leading strategic decision support and shaping long term commercial strategy and execution 

• Influence senior executives across Commercial, Medical, Human Resources, Global Finance, and Corporate functions to align financial plans with enterprise goals. 

• Anticipate market, competitive, and regulatory dynamics and provide actionable insights that guide commercial strategy and resource allocation. 

Financial Strategy, Planning, and Performance Management

• Lead the annual budget, long range planning process, and monthly forecasting cycles for the US Commercial BU, ensuring integration with global planning frameworks. 

• Oversee US revenue and operating expense management and drive analytical rigor and scenario planning to support portfolio optimization and launch readiness. 

• Identify value drivers and enterprise risks and develop innovative, data driven solutions to enable profitable and sustainable growth.

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Leadership, Culture, and Team Development 

• Lead and develop a high performing team with capabilities aligned to Vertex leadership behaviors and culture. 

• Build a culture of accountability, operational excellence, and continuous improvement across the Commercial Finance organization. 

• Partner with HR on workforce planning and organizational design to support the growth of the US Commercial business. 

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Cross Functional Collaboration and Enterprise Influence 

• Partner with Global Commercial Finance, Accounting, Tax, and Investor Relations to strengthen financial systems, processes, and communication. 

• Drive alignment during key business cycles ensuring readiness for launches, lifecycle management, and competitive or market shifts. 

• Represent US Commercial Finance in enterprise forums providing strategic, data driven perspectives that influence business direction. 

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Knowledge and Skills:

• Expert financial modeling, valuation, analytics, and scenario planning capabilities. 

• Strategic thinker with the ability to translate complex information into useful insights for senior leaders. 

• Exceptional executive communication and presentation skills. 

• Ability to lead through ambiguity, drive organizational change, and innovate in a fast paced environment. 

• Deep business acumen and understanding of the biotechnology market and commercial strategy. 

• Demonstrated ability to lead teams and foster an inclusive, development oriented culture. 

• Expertise with Excel and PowerPoint and working knowledge of Hyperion or similar planning tools. 

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Education and Experience:

• Bachelor’s degree in Finance, Accounting, or a related field required.  Master of Business Administration or other advanced degree strongly preferred. 

• Fifteen or more years of progressive finance experience in commercial, FP&A, or strategic roles including experience supporting senior executives or an equivalent combination of education and experience.  Demonstrated success leading financial strategy in a complex and highly regulated environment. 

• Extensive experience in drug development, commercialization, launch planning, pricing, reimbursement, and US market access. 

• Proven ability to influence executives and lead enterprise level initiatives. 

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range:

$212,000 - $318,000

Disclosure Statement:

Flex Designation:

Hybrid-Eligible Or On-Site Eligible

Flex Eligibility Status:

In this Hybrid-Eligible role, you can choose to be designated as:
1. Hybrid: work remotely up to two days per week; or select
2. On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Hybrid

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

About Vertex

Help Us Achieve Our Mission

Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1.

Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 16 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X

We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.