Senior Full-Stack Engineer

Salary Range: $90,000.00 To $110,000.00 Annually Simulations Plus stands as a global leader in model-informed and AI-accelerated drug development. We create value for our clients by accelerating the discovery, development, and commercialization of pharmaceuticals and other products through innovative science-based software and consulting solutions. Leadership truly cares about maintaining a positive culture and employee well-being. We offer fully remote work, flexible schedules, and generous vacation policy along with affordable health coverage, annual bonus, and more! Check out how much our employees love working here: https://www.comparably.com/companies/simulations-plus . The Senior Full-Stack Engineer is a versatile contributor, part of a small department whose charter spans both web/SaaS and AI/agents products. The role will ship features across the full stack — backend, frontend, and LLM-integrated surfaces — wherever the team's most pressing implementation work lands in a given cycle. It's a high-variety role for an engineer who wants to build real depth across web platform and applied-AI engineering, on a deliberately lean team that's growing quickly and intentionally. Department: Product and Technology Internal Grade: 10 Direct Reports: No Status: Exempt Location: Remote Job Responsibilities: Feature Delivery Across the Stack Own features end-to-end across Node.js and Express backends and React/Tailwind frontends Build the APIs, UI, and data flows behind real customer-facing functionality Contribute to the data, auth, and service patterns the platform builds on AI Feature Integration Integrate LLM-powered functionality into product surfaces, working alongside the team's AI lead Wire frontends to LLM and MCP endpoints; handle streaming, errors, and degraded states gracefully Contribute to evals, fixtures, and tooling that support the AI side of the team Team Impact Bring full-stack range to a team that values flexibility across backend, frontend, and AI Contribute to code reviews, documentation, and the team's shared engineering practices Apply AI coding tools effectively as part of daily engineering workflow Other Duties as Assigned Required Qualifications: 3+ years of professional software engineering experience, with shipped full-stack work in production Proficiency in JavaScript or TypeScript across Node.js backend and React frontend Practical experience with document or NoSQL databases such as MongoDB Comfort building and consuming REST APIs and JSON contracts Genuine interest in agents, MCP, and applied AI, and the drive to build real expertise in those areas Fluency using AI coding tools (Claude, Cursor, Copilot) in daily workflow Preferred Qualifications: Familiarity with Anthropic, OpenAI, or other LLM provider SDKs Exposure to MCP, agent frameworks, or LLM-integrated product features Experience with cloud infrastructure (AWS preferred) and CI/CD pipelines Experience in regulated-software environments (SOC 2, HIPAA, GxP, 21 CFR Part 11) or life-sciences SaaS Familiarity with Passport, OAuth, OIDC, or comparable auth patterns Education: Bachelor's degree in computer science, engineering, or related field preferred Relevant technical certifications welcomed Come join the happiest employees in the industry by visiting www.simulations-plus.com/career-center and apply today! Attachments (1) Total Rewards Package 2026.pdf