Senior Manager, Global Digital & Technology Systems Engineering

BeOne continues to grow at a rapid pace with challenging and exciting opportunities for experienced professionals. When considering candidates, we look for scientific and business professionals who are highly motivated, collaborative, and most importantly, share our passionate interest in fighting cancer.

BeOne is a global biopharmaceutical company dedicated to the discovery and development of innovative drug therapies for the treatment of cancer. At BeOne we believe that access to life-changing medicine sees no borders.

The Senior Manager, Global Digital & Technology Systems Engineering is a hands-on technical delivery role within the Systems Engineering capability area, reporting to the Senior Director, Global Digital & Technology Systems Engineering. This role is responsible for executing assigned systems engineering activities across R&D systems, externally developed platforms, integrations, and foundational ML, AI, genAI patterns.

The role translates defined technical standards, architecture direction, implementation plans, and operational expectations into reliable delivery across assigned systems and workstreams. The Senior Manager partners with Global Technology Solutions (Enterprise IT), vendors, R&D stakeholders, and GRDTS peers to ensure solutions align with enterprise infrastructure, cybersecurity, identity management, cloud, operational, and compliance standards.

The Senior Manager contributes practical systems engineering expertise across hybrid cloud, SaaS, high-performance computing (HPC), containerized environments, data pipeline integration, platform observability, and emerging AI architecture patterns including Retrieval-Augmented Generation (RAG), secure AI gateway patterns, agentic workflow orchestration, and multi-modal integration patterns. The role focuses on delivery quality, documentation, issue resolution, operational readiness, and sustained technical supportability.

A successful candidate brings strong technical execution skills, pharmaceutical / biotechnology domain awareness, disciplined delivery practices, and the ability to coordinate day-to-day work across business, vendor, Enterprise IT, and technical contributors. The Senior Manager is expected to raise risks and dependencies early, provide transparent execution updates, and help ensure assigned systems engineering work is scalable, secure, compliant, and fit for R&D scientific and business use.

As ours is a growing team, candidates may be evaluated for other suitable levels.

Essential Functions of the job:

Enterprise IT Alignment & Collaboration

• Execute assigned tasks within the Enterprise IT engagement model, coordinating with Global Technology Solutions to align R&D solutions with infrastructure, cybersecurity, identity management, cloud platform, and operational standards.

• Support technical design reviews, implementation dependency tracking, access / environment coordination, and issue resolution with Enterprise IT, vendors, and R&D stakeholders.

• Document specialized R&D technical needs, constraints, risks, and exceptions for review by the Associate Director and Senior Director.

Platforms & Systems Engineering

• Manage assigned systems engineering activities across on-premises, hybrid cloud, vendor-hosted, and multi-tenant SaaS environments, applying standards established for the Systems Engineering capability area.

• Develop and maintain technical documentation, integration designs, deployment plans, environment details, runbooks, and platform lifecycle artifacts for assigned systems or workstreams.

• Coordinate secure data, digital, and technology integration activities that connect third-party platforms, internal systems, and scientific data flows across defined R&D processes.

• Implement observability, telemetry, monitoring, alerting, and supportability practices for assigned systems to improve reliability, performance, and operational readiness.

• Support configuration, deployment, validation readiness, and operational handoff activities for high-performance computing clusters, containerized environments, storage layers, data lakes, and pipelines supporting compute-heavy R&D use cases.

• Track and execute technical lifecycle activities for assigned systems, including patch coordination, release preparation, codebase / configuration documentation, automated deployment inputs, and transition to steady-state support.

Foundational AI Architectures & Workflow Patterns

• Implement assigned components of RAG architectures, vector store integrations, semantic retrieval layers, chunking strategies, and AI-enabled systems under the direction of the Associate Director and Senior Director.

• Support reusable implementation patterns for agentic AI workflows, secure AI gateway integrations, multi-agent orchestration, and integration controls consistent with enterprise security and intellectual property protections.

• Assist in engineering integration patterns that allow systems to ingest, process, and reason across diverse data types and multi-modal inputs and outputs while maintaining appropriate controls and compliance expectations.

Change Management & Digital Adoption

• Execute technical change activities for assigned infrastructure modernization, cloud migration, integration, and platform adoption workstreams in collaboration with Global Technology Solutions and R&D stakeholders.

• Prepare and maintain technical impact assessments, adoption inputs, cutover checklists, support handoff materials, and release readiness documentation for leadership review.

• Help teams apply consistent integration standards, system documentation practices, and operational readiness expectations across assigned technology workstreams.

Governance & Risk Mitigation

• Apply architecture, security, compliance, and operational controls for assigned systems, including data protection expectations, secure AI gateway patterns, sandboxing requirements, and vendor risk inputs.

• Identify, document, and escalate technical risks, architectural constraints, support gaps, compliance considerations, and execution dependencies to the Associate Director and Senior Director.

• Coordinate with audit, compliance, CSV, cybersecurity, Enterprise IT, and vendor partners to support applicable pharmaceutical industry, GxP, computer systems validation, and internal policy requirements.

Operational Excellence, Compliance & Governance:

• Maintain disciplined use of engineering documentation, technical decision records, risk logs, implementation checklists, support artifacts, and operational handoff materials for assigned work.

• Ensure assigned systems and platforms are implemented and operated in line with relevant pharmaceutical regulations, internal policies, security standards, and validation expectations.

Collaboration & Partnership:

• Collaborate with R&D functional teams, Enterprise IT, vendors, and GRDTS peers to execute workstream objectives and improve delivery quality.

• Provide clear status, issue, dependency, and decision updates to the Associate Director and Senior Director to support transparency and timely leadership action.

Supervisory Alignment:

• Reports to the Senior Director, Global Digital & Technology Systems Engineering; works in close coordination with the Associate Director on assigned workstream priorities, standards, and execution expectations.

• No direct line-management responsibilities are required for this role. Provides day-to-day technical coordination for assigned systems engineering workstreams, project contributors, vendor resources, and matrixed technical teams.

• Coaches team members and partners on systems engineering practices, technical documentation, integration standards, observability, operational readiness, and compliance expectations.

Key Capabilities :

• Enterprise-to-R&D Infrastructure Execution: Applying Enterprise IT standards to assigned R&D platform designs and escalating specialized research requirements, risks, and exceptions through the Associate Director and Senior Director.

• External Platform Technical Assessment: Supporting technical assessment of vendor and externally developed platforms for scalability, security, architecture quality, integration readiness, supportability, and alignment with Enterprise standards.

• Internal & Vendor Platform Integration: Coordinating secure and maintainable integration activities that connect internal applications, scientific workflows, data pipelines, and third-party platforms.

• Full-Ecosystem Observability & Reliability: Implementing monitoring, telemetry, alert routing, runbooks, and support readiness practices for assigned internal and vendor-hosted applications.

• Advanced Compute & AI Architecture Implementation: Supporting implementation of cloud, high-performance computing, RAG pipeline, secure AI gateway, and agentic workflow patterns within approved architecture direction.

• Technical Governance & Execution Discipline: Applying unified architecture standards and maintaining reusable documentation, templates, and engineering artifacts for assigned systems and workstreams.

Key Competencies :

• Objective Technical Analysis: Reviews architecture diagrams, APIs, integration patterns, operational models, and vendor materials to identify technical readiness, risk, and delivery implications.

• Enterprise & Domain Collaboration: Works effectively with Enterprise IT and R&D stakeholders, balancing enterprise constraints with scientific and operational needs.

• Ecosystem-Level System Thinking: Understands internal applications, vendor platforms, data pipelines, cloud infrastructure, and AI patterns as connected parts of a broader R&D technology ecosystem.

• Enterprise Risk & IP Stewardship: Maintains appropriate attention to data protection, proprietary information, intellectual property, security, and regulated system expectations.

• Execution-Oriented Change Leadership: Helps teams move through technical change, adoption, documentation, and operational readiness while reinforcing standards and accountability.

• Resilient Issue Management: Provides structured technical coordination during upgrades, integration issues, infrastructure changes, and production incidents, with timely escalation as needed.

Key Deliverables :

• Assigned Workstream Technical Plans: Implementation plans, dependencies, environment details, risks, and architecture documentation for assigned systems engineering activities.

• Vendor Technical Assessment Inputs: Technical review notes, integration feasibility inputs, risk observations, and security / supportability inputs for proposed third-party solutions.

• Reusable Engineering Artifacts: Technical documentation, reference materials, configuration notes, implementation checklists, and templates for integration, AI, observability, and operational readiness patterns.

• Observability & Operational Readiness Materials: Monitoring requirements, telemetry specifications, runbooks, alerting inputs, support handoff materials, and readiness checklists for assigned platforms.

• Governance, Compliance & Technical Alignment Inputs: Risk logs, validation inputs, compliance documentation, architecture review materials, and Enterprise IT alignment inputs prepared for review by the Associate Director and Senior Director.

Technical Qualifications:

• Hands-on programming experience with Python and SQL for automation, data pipeline integration, API testing, platform scripting, and technical troubleshooting.

• Working knowledge of JavaScript / TypeScript for web application integration, workflow automation, and lightweight front-end or API-driven solution delivery.

• Experience with scripting and automation using Bash, PowerShell, or equivalent tools for deployment support, environment configuration, log analysis, and operational runbooks.

• Familiarity with R for scientific, statistical, or analytics workflows is preferred; exposure to Java, C#, or similar enterprise application languages is a plus.

• Practical understanding of REST APIs, event-driven integration, JSON / XML data exchange, authentication patterns, and secure system-to-system connectivity.

• Experience with cloud and platform engineering practices across AWS and/or Azure, including compute, storage, networking, identity, access controls, monitoring, and cost-aware resource usage.

• Working knowledge of containers and orchestration technologies such as Docker and Kubernetes, plus infrastructure-as-code or configuration automation tools such as Terraform, CloudFormation, Ansible, or similar.

• Familiarity with DevOps and release practices, including Git, branching strategies, pull request reviews, CI/CD pipelines, deployment documentation, automated testing inputs, and environment promotion controls.

• Technical awareness of high-performance computing (HPC), Linux environments, job schedulers, storage layers, and workload patterns supporting compute-intensive scientific use cases.

• Applied knowledge of ML / AI / genAI implementation patterns, including retrieval-augmented generation (RAG), embeddings, vector databases, semantic search, model integration, prompt / response controls, secure AI gateways, and agentic workflow orchestration.

• Ability to implement observability and supportability practices using logs, metrics, traces, telemetry, alerting, dashboards, runbooks, and incident / problem management workflows.

• Understanding of cybersecurity, identity and access management, data protection, intellectual property safeguards, vendor-hosted platform controls, GxP computer systems validation, and 21 CFR Part 11 expectations in regulated R&D environments.

Qualifications:

• Bachelor's degree or above

• 3+ years of professional experience in data, digital, information technology, AI, systems engineering, cloud, infrastructure, integration, platform engineering, or related technical delivery roles, preferably in Pharmaceutical, Biotechnology, and/or Medical Device industries.

• Experience coordinating technical work across cross-functional, matrixed, vendor, Enterprise IT, or engineering teams through system design, implementation, supportability, and operationalization activities.

• Practical experience with systems engineering for externally developed platforms, SaaS solutions, integration architectures, observability practices, cloud / hybrid infrastructure, and technical application lifecycle activities.

• Hands-on experience with ML/AI/genAI end-to-end development & deployment from a systems engineering perspective, including RAG, vector stores, AI gateways, agentic workflows, and secure integration patterns.

• Ability to partner with Enterprise IT, cybersecurity, infrastructure, cloud, identity management, compliance, audit, vendors, and R&D stakeholders to execute technically sound and compliant solutions.

• Working knowledge of software lifecycle methodologies, GxP computer systems validation (CSV), 21 CFR Part 11 expectations, and pharmaceutical industry compliance considerations.

• Strong communication, documentation, technical analysis, issue management, and stakeholder coordination skills, with the ability to translate technical details into clear decisions, risks, dependencies, and action plans.

• Proficient in project and delivery practices such as Agile, Scrum, Kanban, Lean, release management, and operational readiness planning.

Travel:

• Some travel expected as part of assigned duties

BeOne Global Competencies:

When we exhibit our values of Patients First, Collaborative Spirit, Bold Ingenuity and Driving Excellence, through our twelve global competencies below, we help get more affordable medicines to more patients around the world.

• Fosters Teamwork
• Provides and Solicits Honest and Actionable Feedback
• Self-Awareness
• Acts Inclusively
• Demonstrates Initiative
• Entrepreneurial Mindset
• Continuous Learning
• Embraces Change
• Results-Oriented
• Analytical Thinking/Data Analysis
• Financial Excellence
• Communicates with Clarity

Global Competencies

When we exhibit our values of Patients First, Driving Excellence, Bold Ingenuity and Collaborative Spirit, through our twelve global competencies below, we help get more affordable medicines to more patients around the world.

• Fosters Teamwork
• Provides and Solicits Honest and Actionable Feedback
• Self-Awareness
• Acts Inclusively
• Demonstrates Initiative
• Entrepreneurial Mindset
• Continuous Learning
• Embraces Change
• Results-Oriented
• Analytical Thinking/Data Analysis
• Financial Excellence
• Communicates with Clarity

Salary Range: $136,900.00 - $181,900.00 annually

BeOne is committed to fair and equitable compensation practices. Actual compensation packages are determined by several factors that are unique to each candidate, including but not limited to job-related skills, depth of experience, certifications, relevant education or training, and specific work location. Packages may vary by location due to differences in the cost of labor. The recruiter can share more about the specific salary range for a preferred location during the hiring process. Please note that the listed range reflects the base salary or hourly range only. Non-Commercial roles are eligible to participate in the annual bonus plan, and Commercial roles are eligible to participate in an incentive compensation plan. All Company employees have the opportunity to own shares of BeOne Medicines Ltd. stock because all employees are eligible for discretionary equity awards and to voluntarily participate in the Employee Stock Purchase Plan. The Company has a comprehensive benefits package that includes Medical, Dental, Vision, 401(k), FSA/HSA, Life Insurance, Paid Time Off, and Wellness.

We are proud to be an equal opportunity employer. BeOne does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, disability, national origin, veteran status or any other basis covered by appropriate law. All employment is decided on the basis of qualifications, merit, and business need. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans’ Readjustment Assistance Act of 1974, Title I of the Americans with Disabilities Act of 1990, and any other applicable federal, state or local laws, applicants who require reasonable accommodation in the job application process may contact accommodationsus@beonemed.com.

About Us

BeOne is a global oncology company that is discovering and developing innovative treatments that are more affordable and accessible to cancer patients worldwide. With a broad portfolio, we are expediting development of our diverse pipeline of novel therapeutics through our internal capabilities and collaborations. We are committed to radically improving access to medicines for far more patients who need them. Our growing global team of more than 11,000 colleagues spans six continents. To learn more about BeOne, please visit www.beonemedicines.com and follow us on LinkedIn, X (formerly known as Twitter), Facebook and Instagram.

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BeOne Values

At BeOne, how we work is just as important as the work we do. Below are our Values that determine the decisions we make and how we do things.

• Patients First

• Driving Excellence

• Bold Ingenuity

• Collaborative Spirit