Director, Portfolio Strategy and Management

Use Your Power for Purpose
At Pfizer, our purpose is breakthroughs that change patients’ lives and our colleagues make this happen. All over the world, our colleagues work together to touch millions of lives.

What You Will Achieve

The Director, Portfolio Strategy & Management shapes the strategic direction of the Global Hospital & Biosimilars (GH&B) portfolio by developing enterprise recommendations on where the business should grow, defend, improve, simplify, or exit. The Director leads and advises high-priority portfolio assessments, identifies strategic opportunities and emerging business questions, and partners across functions to deliver rigorous, evidence-based recommendations. These recommendations integrate commercial, financial, operational, manufacturing, regulatory, and strategic considerations; clearly articulate trade-offs and enterprise implications; and enable timely decisions through the Global Portfolio Forum and other governance bodies.

Success in this role requires maintaining clear, current strategic direction for priority portfolios; advancing assessments in line with business priorities; proactively identifying, sizing, and prioritizing future opportunities; and resolving cross-functional trade-offs to support effective execution. The Director also helps evolve GH&B’s portfolio operating model, assessment methodology, and future opportunity agenda to strengthen enterprise alignment and value creation.

How You Will Achieve It

Portfolio Strategy and Recommendations

• Lead Annual Portfolio Review and own portfolio recommendations across GH&B value chains, identifying where to grow, defend, improve, simplify, rationalize, or exit.
• Translate strategic theses into decision-ready recommendations with explicit assumptions, risks, trade-offs, dependencies, and enterprise implications.
• Ensure recommendations balance commercial opportunity, network realities, operational feasibility, financial returns, and long-term enterprise value.
• Present and defend recommendations in the Global Portfolio Forum and other governance forums as required.
• Maintain a current portfolio opportunity pipeline beyond committed programs and proactively elevate emerging opportunities and risks.

Portfolio Assessments and Deep Dives

• Lead, co-lead, and/or provide strategic advise for high-priority portfolio assessments, determining the appropriate scope, analytical approach, level of evidence, and cross-functional engagement required to progress each opportunity toward a decision.
• Assemble and direct cross-functional teams from Commercial, Manufacturing, Finance, Regulatory, Medical, Quality, Digital, and market organizations as appropriate.
• Determine which opportunities require hands-on leadership, which should be led by project teams with strategic oversight, and which require further evidence before governance consideration.
• Following approval, transition recommendations to execution owners with assumptions, risks, dependencies, and expected value clearly documented.
• Guide recommendations from assessment through governance and transition to execution, ensuring decision requests, supporting rationale, assumptions, risks, dependencies, expected value, and ownership are clearly documented; reassess recommendations when material facts change.

Portfolio Assessment Frameworks

• Own and continuously improve the GH&B value assessment methodology. Ensure recommendations are evaluated consistently across financial, commercial, operational, manufacturing, regulatory, and strategic dimensions.
• Define the decision questions, metrics, analytical views, and visualization capabilities needed to generate actionable portfolio insights; apply artificial intelligence-enabled analytics responsibly to identify patterns, outliers, margin erosion, capacity constraints, growth signals, and optimization opportunities while ensuring validated data lineage, transparent assumptions, and appropriate human judgment.

Portfolio Performance Dashboards & Visualizations

• Define the strategic decision questions, performance measures, and analytical views required to evaluate portfolio health, value creation, and emerging opportunities across GH&B.
• Shape and advance AI-enabled analytics and visualization capabilities that identify material portfolio patterns, outliers, margin erosion, capacity constraints, growth signals, and optimization opportunities.
• Establish scalable and reusable approaches that accelerate the path from business question to decision-ready insight, reducing reliance on bespoke manual analysis and enabling appropriate self-service access.
• Translate portfolio performance signals into actionable optimization opportunities, applying enterprise judgment to size, prioritize, and sequence opportunities within the portfolio pipeline.
• Set expectations for decision-grade portfolio insights by ensuring appropriate data validation, transparent assumptions, traceable data lineage, and human judgment before AI-generated outputs inform enterprise recommendations.

Enterprise Partnership and Influence

• Build and leverage trusted enterprise partnerships across Commercial, Manufacturing, Finance, Regulatory, Quality, Digital, and market organizations to shape integrated portfolio recommendations and advance shared priorities.
• Anticipate, surface, and facilitate resolution of cross-functional implications, dependencies, and trade-offs during recommendation development, strengthening alignment and reducing downstream execution risk.
• Integrate external perspectives into portfolio strategy by evaluating relevant market trends, competitive developments, evolving customer needs, and industry practices for their potential enterprise impact.
• Represent and advocate for the enterprise perspective when functional, geographic, or market priorities compete, using influence and sound judgment to guide stakeholders toward decisions that optimize long-term portfolio value.

Here Is What You Need (Minimum Requirements)

• Applicant must have a bachelor's degree with at least 8 years of
  experience; OR a master's degree with at least 7 years of experience; OR a PhD with 5+ years of experience

• Broad pharmaceutical experience in Commercial, Manufacturing, Supply Chain, Finance, Regulatory, or related functions to solve complex enterprise problems.

• Candidates should demonstrate most of the following capabilities through a combination of professional experience, business impact, and leadership achievements:

• Experience within sterile injectables, biosimilars, specialty medicines, hospital products.
• Experience shaping and influencing significant portfolio, investment, operational, commercial, or strategic business decisions.
• Strong financial acumen, including the ability to interpret business cases, product economics, P&L performance, margin drivers, stranded costs, and capacity trade-offs.
• Demonstrated ability to evaluate competing priorities and make recommendations under uncertainty using incomplete information.
• Experience using portfolio analytics, scenario modeling, visualization tools, or AI-enabled analytical capabilities.
• Experience leading cross-functional initiatives and influencing senior stakeholders without formal authority.
• Strong executive communication skills, including the ability to frame choices, risks, trade-offs, and recommendations for leadership audiences.
• Enterprise mindset with the ability to balance local, functional, and business-unit interests against broader organizational objectives.
• Experience applying, building, improving, or governing portfolio, investment, prioritization, or value assessment frameworks.

• undefined
• Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

Bonus Points If You Have (Preferred Requirements)

• Strategy consulting, corporate strategy, corporate development, portfolio management, or business transformation experience.
• Experience in manufacturing network strategy, footprint optimization, supply strategy, or portfolio rationalization.
• Demonstrated leadership in enterprise-wide transformation, strategic planning, or portfolio optimization initiatives.

Non-Standard Work Schedule, Travel or Environment Requirements

Occasional business travel, 10-15%

Work Location Assignment: Hybrid

The annual base salary for this position ranges from $162,900.00 to $271,500.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 20.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.


This role is posted in multiple locations. If you are applying for the role in an secondary job posting location where pay transparency regulations apply, your Talent Advisor will share the local pay information with you during the first interview.



Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.

U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

To learn more about acceptable and prohibited uses of AI during the recruitment process, please review our candidate AI-use guidelines available on Pfizer Careers.

Marketing and Market Research