Global Medical Affairs Lead, GI Oncology

Location: Gaithersburg, Maryland, United States
Working model: Hybrid, with an expected onsite presence three days per week
Travel: Approximately 30%, including domestic and international travel
Relocation support: May be available

Disrupt to redefine cancer treatment

At AstraZeneca, we are working to transform cancer care. We follow science, challenge convention and collaborate across boundaries to deliver meaningful advances for patients.

Within Medical Affairs, we generate and communicate compelling medical evidence that can change clinical practice and improve the patient experience. By bringing together science and strategy, we help healthcare professionals make informed decisions and accelerate the delivery of innovative medicines to patients.

We are seeking a Global Medical Affairs Lead, GI Oncology, to provide strategic medical leadership for our expanding hepatobiliary portfolio, including hepatocellular carcinoma and biliary tract cancer.

This is an opportunity to shape the medical strategy for a complex and evolving portfolio, prepare global markets for critical launches and contribute to the development of emerging treatment approaches, including next-generation molecules and novel modalities.

What you’ll do

As the accountable medical leader assigns GI oncology indications and assets, you will shape and deliver the Global Medical Strategy, connecting Medical Affairs, R&D and Commercial teams to advance the portfolio and prepare markets for launch.

Develop and execute Global Medical Plans, setting priorities and adapting strategy based on scientific developments, external insights and performance.
Lead medical launch readiness and ensure global strategies are translated into relevant regional and country plans.
Influence clinical development, evidence generation and lifecycle planning by representing Medical Affairs on key cross-functional teams.
Identify evidence gaps and lead integrated evidence plans across clinical, real-world, diagnostic and digital sources.
Shape Medical Affairs studies and lead global publication and scientific communication strategies.
Develop a clear scientific narrative across publications, medical education, congresses and external engagement.
Build strategic relationships with external experts, professional societies, health systems and other scientific organizations.
Lead complex global matrix teams, build stakeholder alignment and strengthen Medical Affairs capabilities through coaching and mentorship.

Essential requirements

Advanced medical or scientific degree, such as an MD, PhD, PharmD or equivalent.
+3 years of Medical Affairs experience within the pharmaceutical or biotechnology industry, typically gained at country, regional or global level.
+3 years of demonstrated experience in oncology.
+3 years of experience developing or leading Medical Plans, evidence-generation strategies, publications or scientific communication programs.
+3 years of experience supporting an oncology launch or preparing a market for launch
Demonstrated success working in a complex, cross-functional matrix involving Medical Affairs, R&D and Commercial stakeholders.
Proven ability to influence senior stakeholders and translate scientific evidence into strategic recommendations.
Experience engaging external experts and scientific communities.
Strong scientific communication, stakeholder-management and leadership skills.

Desirable qualifications

Experience in gastrointestinal oncology, hepatocellular carcinoma, biliary tract cancer or another hepatobiliary malignancy.
Experience in immuno-oncology or immunotherapy.
Experience with new mechanisms of action, emerging treatment modalities, companion diagnostics or complex biomarker strategies.
Exposure to novel modalities such as cell therapy or bispecific molecules.
Experience leading matrix teams across complex or multi-indication portfolios.

Why AstraZeneca?

In Medical Affairs, we combine scientific expertise with strategic leadership to help change the practice of medicine. We are valued partners to R&D and Commercial, translating evidence into clinical practice and helping innovative medicines achieve their full potential for patients.

You will join an open, ambitious and collaborative global organization where you can work at the cutting edge of oncology science, learn from experts across the enterprise and take ownership of your professional development.

This newly created position supports the continued expansion of our hepatobiliary program. It offers the opportunity to:

Shape the medical strategy for a scientifically complex and evolving oncology portfolio.
Prepare global markets for important future launches.
Influence evidence generation and development strategy.
Work with emerging mechanisms and treatment modalities.
Build broad global leadership experience across Medical Affairs, R&D and Commercial.
Grow toward wider and more senior medical leadership opportunities.

Life at our Gaithersburg site

Our Gaithersburg site brings together an international scientific community united by a passion for advancing science and improving patients’ lives. The collaborative environment encourages knowledge sharing, entrepreneurial thinking and cross-functional partnership.

Located near leading universities, research institutions and the Washington, DC area, Gaithersburg offers access to a vibrant scientific ecosystem as well as a diverse and welcoming community.

Compensation and benefits

The annual base pay for this position ranges from $ 206,827.20 - $310,240.80 USD. The base pay offered may vary depending on individualized factors, including market location and the successful candidate’s job-related knowledge, skills and experience.

In addition, this position offers a short-term incentive bonus opportunity and eligibility to participate in AstraZeneca’s equity-based long-term incentive program, subject to the terms of the applicable plans.

Benefits include a qualified retirement program, paid vacation and holidays, paid leaves, and health benefits including medical, prescription drug, dental and vision coverage. Additional information regarding participation in these plans will be provided if an applicant receives an offer of employment.

Ready to make an impact?

Bring your Medical Affairs expertise, oncology experience and strategic leadership to a role where you can shape an emerging portfolio, influence the development and launch of innovative medicines, and help transform outcomes for people affected by gastrointestinal cancers.

Apply today and help us redefine the future of cancer care.

Date Posted

09-Oct-2026

Closing Date

22-Oct-2026

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

About Us

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We

focus on discovering, developing and commercialising prescription medicines for some

of the world’s most serious diseases. But we are more than one of the world’s leading

pharmaceutical companies.

At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered

to push the boundaries of science, challenge convention and unleash your entrepreneurial

spirit. To embrace differences and take bold actions to drive the change needed to meet

global healthcare and sustainability challenges.

There is no better place to make a difference in medicine, patients, and society. An inclusive

culture where you will connect different thinking to generate new and valuable opportunities.

Where you will find a commitment to lifelong learning, growth and development for all.

Championing Inclusion and Diversity

Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients.

Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking.

Life at AstraZeneca

We’re curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We’re driven to make the right choices and be accountable for our actions.

As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential.

Here, you’ll do work that has the potential to change your life and improve countless others. And, together with your team, you’ll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.

Global Medical Affairs Lead, GI Oncology