Group Leader, Oligonucleotide Chemistry

Shape the Future of RNA Medicines as Group Leader, Oligonucleotide Chemistry

Singapore | Full-Time | RNA Therapeutics

A pioneering biotechnology company at the forefront of RNA therapeutic innovation is seeking a Group Leader, Oligonucleotide Chemistry to lead its specialised oligonucleotide chemistry platform and support the development of next-generation RNA medicines.

This is a unique opportunity to combine scientific leadership with hands-on innovation, taking on a role that will be driving the discovery and advancement of RNA-based therapeutics from concept through to candidate selection.

The Company

The organisation is a rapidly growing biotechnology innovator focused on harnessing the potential of RNA-based medicines to address significant unmet medical needs. Combining cutting-edge science with a highly collaborative research environment, the company is advancing a pipeline of novel therapeutics across a range of disease areas and continues to invest in expanding its world-class discovery capabilities.

The Role

As Group Leader, Oligonucleotide Chemistry, the successful candidate will lead oligonucleotide synthesis, purification, and analytical characterisation activities while managing and developing a high-performing team of scientists. The role will be instrumental in expanding the company's chemistry capabilities, integrating emerging technologies, and supporting multiple therapeutic discovery programmes.

Key Responsibilities

• Establish, optimise, and scale high-throughput solid-phase oligonucleotide synthesis (SPOS) workflows for ASOs, siRNA, SSOs, RNA editing applications, and emerging oligonucleotide modalities.
• Lead, mentor, and develop a team of scientists and research associates, fostering a culture of scientific excellence, collaboration, and innovation.
• Partner closely with biology, delivery, analytical, and preclinical teams to advance programmes towards candidate nomination and development.
• Manage external collaborators and CRO partnerships while maintaining strategic in-house expertise and capabilities.
• Contribute to the evaluation and implementation of new technologies that enhance oligonucleotide discovery and development capabilities.
• Support intellectual property generation, technical reports, presentations, and broader scientific strategy where required.

About You

• PhD in Chemistry, Organic Chemistry, Medicinal Chemistry, Chemical Biology, or a related discipline.
• Significant industry experience in oligonucleotide drug discovery and development.
• Strong technical knowledge of SPOS technologies, purification methodologies, and LC-MS/UPLC analytical platforms.
• Proven track record of advancing oligonucleotide therapeutics within biotechnology or pharmaceutical environments.
• Demonstrated leadership experience with a passion for mentoring and developing scientific talent.

What's on Offer

• Competitive salary and benefits package aligned with global industry standards.
• The opportunity to work at the forefront of RNA therapeutic innovation.
• Access to world-class scientific infrastructure and multidisciplinary expertise.
• Clear opportunities for career progression, leadership development, and professional growth.
• Relocation support and comprehensive benefits, where applicable.

If you are passionate about advancing breakthrough RNA medicines and leading innovative oligonucleotide chemistry programmes, Apply Now.