Medical Director, Enfortumab Vedotin

ROLE SUMMARY The Medical Director will serve as a physician within the Enfortumab vedotin Oncology Late Development team, contributing to the development and execution of clinical strategies that advance transformative therapies for patients with cancer. This role combines study-level clinical leadership with broader strategic contributions across the asset lifecycle. Working in close partnership with Clinical Scientists, Worldwide Medical, Translational Oncology, Biostatistics, Safety, Regulatory, and other cross-functional stakeholders, the Medical Director will help generate evidence that addresses both regulatory requirements and the evolving needs of patients, healthcare providers, and healthcare systems. The successful candidate will bring strong scientific and clinical judgment, an interest in strategic drug development, and a collaborative mindset. This individual will be expected to leverage emerging technologies, including AI-enabled tools and advanced analytics, to enhance decision-making, accelerate insights generation, and improve operational efficiency. ROLE RESPONSIBILITIES Clinical Development Leadership Provide clinical leadership for clinical study teams, ensuring scientific rigor, patient focus, and alignment with program objectives. Partner closely with Clinical Scientists and cross-functional colleagues to deliver high-quality study execution and data generation. Conduct medical monitoring activities, including eligibility review, safety surveillance, data review, and clinical issue management. Lead peer-to-peer scientific engagement with investigators and key external experts. Serve as the clinical point of contact for investigators, ethics committees, steering committees, and regulatory authorities. Contribute to the design, development, and maintenance of clinical protocols, amendments, clinical study reports, investigator materials, and regulatory documentation. Strategic Development & Evidence Generation Contribute to the development of clinical and evidence-generation strategies that support both regulatory objectives and broader patient and healthcare stakeholder needs. Apply evolving understanding of the oncology landscape, standard of care, and competitive environment to inform development decisions and study planning. Collaborate with Worldwide Medical and cross-functional partners to ensure alignment of evidence generation priorities throughout the product lifecycle. Support identification of opportunities to optimize development programs through innovative trial design, external insights, and emerging scientific advancements. Data Interpretation & Insight Generation Partner with Clinical Scientists and quantitative functions to review, interpret, and communicate clinical data and emerging evidence. Translate complex clinical findings into actionable insights that guide program-level decisions and future development plans. Utilize advanced analytics and AI-enabled tools to enhance data synthesis, knowledge generation, and operational efficiency. Contribute to scientific communications, publications, congress presentations, and internal governance discussions as appropriate. Collaboration & External Engagement Foster strong partnerships across Clinical Development, Worldwide Medical, Safety, Regulatory, Biometrics, Translational Sciences, and Commercial colleagues as appropriate. Maintain awareness of emerging scientific, clinical, and healthcare trends relevant to the therapeutic area. Engage with external experts, investigators, and scientific communities to gather insights that inform development strategy. Promote a culture of innovation, continuous learning, and patient-centered drug development. BASIC QUALIFICATIONS MD, DO, or equivalent medical degree. 2-5 years of pharmaceutical, biotechnology, academic research, or clinical development experience. Demonstrated understanding of clinical research methodology and drug development. Strong scientific communication and cross-functional collaboration skills. PREFERRED QUALIFICATIONS Board certified or board eligible in Oncology, Hematology/Oncology, or related specialty. Experience supporting oncology clinical trials. Understanding of late-stage clinical development, evidence generation, and the oncology treatment landscape. Ability to interpret complex clinical data and translate findings into strategic insights. Experience utilizing digital, analytical, or AI-enabled tools to support decision making and drive efficiency. Demonstrated ability to work effectively across matrixed organizations and influence without authority. Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact. Relocation support available Work Location Assignment: Hybrid The annual base salary for this position ranges from $239,900.00 to $399,800.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 25.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States. This role is posted in multiple locations. If you are applying for the role in an secondary job posting location where pay transparency regulations apply, your Talent Advisor will share the local pay information with you during the first interview. Relocation assistance may be available based on business needs and/or eligibility. Candidates must be authorized to be employed in the U.S. by any employer. U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future. Sunshine Act Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative. EEO & Employment Eligibility Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States. Pfizer endeavors to make www.pfizer.com/careers accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email [email protected] . This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned. To learn more about acceptable and prohibited uses of AI during the recruitment process, please review our candidate AI-use guidelines available on Pfizer Careers . Medical