Executive Director, GCS Immunology — POVE

Job Description

General Summary:

The Executive Director, Global Commercial Strategy (GCS) Immunology - Pove will be the senior commercial leader for the non-kidney diseases and indications where povetacicept is most likely to first commercialize: generalized myasthenia gravis (gMG), Sjögren’s disease (SjD), and potentially lupus, including systemic lupus erythematosus (SLE) and lupus nephritis (LN). The role will own the disease and commercial strategy across these Immunology indications, with kidney indications led separately within the Kidney vertical.

The Executive Director will co-lead the povetacicept Immunology Program Team with the Development Lead, guiding strategy and key development and investment decisions for the non-kidney portfolio. The role will lead near-term commercial assessments for gMG and SjD and build global commercialization and launch plans for indications that advance.

Key Duties & Responsibilities

• Co-lead the povetacicept Immunology Program Team with the Development Lead, setting the strategy, priorities, and decision framework for gMG, SjD, SLE, and LN.
• Own the disease and commercial strategy for gMG, SjD, and lupus, building deep understanding of the markets and requirements for success.
• Lead the commercial assessment and recommendation for the upcoming gMG decision, including the target product profile, differentiation, evidence needs, opportunity, forecast, risks, and launch implications.
• Rapidly develop the commercial recommendation and business case for whether and how to advance povetacicept into Phase 2 development in SjD.
• Shape development plans by defining commercially meaningful populations, endpoints, comparators, evidence requirements, differentiation thresholds, and lifecycle opportunities.
• Lead commercial development activities, including market research, forecasting, competitive intelligence, scenario planning, target product profiles, and investment recommendations.
• Develop the global commercialization strategy across the non-kidney Immunology indications, including sequencing, positioning, evidence generation, and resource priorities.
• Lead global launch preparation for indications that advance, including critical success factors, market development, regional alignment, readiness milestones, and cross-functional execution.
• Partner with the GCS Kidney lead and across Development, Medical, Regulatory, Value & Access, Finance, and regional Commercial teams to ensure povetacicept strategies are aligned while maintaining clear accountability by vertical.
• Communicate clear recommendations to senior leaders and governance bodies, identifying key uncertainties, trade-offs, risks, and actions required.
• Build and lead a high-performing Immunology commercial team as the portfolio advances.

Required Education Level

• Minimum of a Bachelor’s degree in business, marketing, life sciences, healthcare, or a related field.
• Advanced degree such as an MBA, M.S., Pharm.D., Ph.D., or M.D. preferred.

Required Experience

• Extensive biopharmaceutical commercial experience, including global commercial strategy, new product planning, or marketing leadership.
• Demonstrated experience shaping pipeline assets and translating market insight into development strategy, evidence requirements, and investment decisions.
• Strong experience leading commercial assessments, forecasts, business cases, and scenario analyses for pre-launch assets.
• Launch experience in specialty, rare disease, neurology, rheumatology, immunology, or other complex markets; direct Immunology experience strongly preferred.
• Experience leading cross-functional teams in a matrixed environment; program-team leadership experience preferred.
• Exceptional strategic thinking, analytical rigor, business judgment, communication, and influencing skills.
• Proven people leadership and ability to build collaborative, high-performing teams.
  
  

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range:

Disclosure Statement:

Flex Designation:

Flex Eligibility Status:

In this Hybrid-Eligible role, you can choose to be designated as:
1. Hybrid: work remotely up to two days per week; or select
2. On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

About Vertex

Help Us Achieve Our Mission

Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1.

Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 17 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visitwww.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X

We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.