Executive Director, Trade and Distribution

Company Background

The mission of Neurogene is to treat devastating neurological diseases to improve the lives of patients and families impacted by these rare diseases. Neurogene is developing novel approaches and treatments to address the limitations of conventional gene therapy in central nervous system disorders. This includes selecting a delivery approach to maximize distribution to target tissues and designing products to maximize potency and purity for an optimized efficacy and safety profile. The Company’s novel and proprietary EXACT transgene regulation platform technology allows for the delivery of therapeutic levels while limiting transgene toxicity associated with conventional gene therapy.

Neurogene has constructed a state-of-the-art gene therapy manufacturing facility in Houston, Texas. CGMP production of NGN-401 was conducted in this facility and will support pivotal clinical development activities. This transformative work is driven by our highly collaborative people who come together each day to bring us closer to achieving our mission. As an employee of Neurogene, you will be part of building a culture that honors patient and caregiver mindsets and nurtures innovation, creative problem solving and a strong sense of purpose.

Position Overview –

Work Location: Remote – Reports to VP, Commercial Supply Chain

The Executive Director of Trade & Distribution leads Neurogene’s product channel strategy and day-to-day execution of patient supply. The role is responsible for ensuring product availability, maintaining effective relationships with distribution and specialty pharmacy partners, and managing the financial and operational performance of the channel. This position works closely with Market Access, Finance, Supply Chain, Legal, Compliance, Regulatory Affairs, Quality Assurance, and Commercial Operations to support patient and provider access while managing channel costs and performance.

Accountabilities and Responsibilities

• Lead the implementation of Neurogene’s Trade and Distribution strategy, including 3PL, specialty distributors and specialty pharmacy partners.

• Manage distributor and specialty pharmacy relationships, contracts, service levels, business reviews and day-to-day operational issues.

• Negotiate and manage commercial terms, including distribution service fees, order-level discounts, prompt-pay discounts and other channel fees.

• Partner with Finance and Market Access to evaluate the gross-to-net impact of trade programs, discounts, fees and contracting decisions.

• Monitor inventory, days on hand, ordering trends and product availability across the distribution network.

• Oversee specialty pharmacy channel performance, including product access, fulfillment and coordination with HUB services.

• Support pricing changes and ensure accurate implementation across distributors, pharmacies and other trade partners.

• Oversee trade-related chargebacks, returns, replacements and customer escalations.

• Develop and review regular reporting on shipments, sales, inventory, customer purchasing patterns and channel performance.

• Evaluate and manage vendors that support trade, distribution, patient access and commercial operations.

• Lead trade and distribution planning for product launches, channel changes and other commercial initiatives.

• Serve as the internal subject-matter expert for trade and distribution and provide updates and recommendations to senior leadership.

Minimum Requirements

Education

• Bachelor’s Degree required; Advanced degree preferred

Experience

• 12+ years of pharmaceutical or biotech commercial experience, with significant

experience in Trade & Distribution, Specialty Pharmacy, Market Access or related

functions

Knowledge, Skills and Attributes

• Strong knowledge of pharmaceutical distribution, specialty pharmacy, 3PL operations,

channel contracting and gross-to-net economics.

• Experience with physician-administered, buy-and-bill or medical-benefit products

preferred.

• Strong negotiation, financial and analytical skills with the ability to manage both

strategic and operational priorities.

• Ability to work effectively across functions and with external partners in a fast-paced

commercial environment.

• Continuous strong focus on meeting or exceeding expectations in executing

deliverables, performance and results.

• Ability to track and measure performance against defined metrics.

• Self-starter with high degree of energy, independence, initiative, and self-motivation,

as illustrated by the ability to instill a sense of pace and urgency into the team.

• Someone who moves fast and decisively in a balanced manner, with a passion for the

growing company.

• Passionate, collaborative, creative, willing to take prudent risks, and motivated by the

creation of a company focused on transformative treatments for patients and their families.

This job description has been developed based upon the expected and current duties, responsibilities and requirements for the position. Because job requirements evolve with the changing needs of Neurogene’s business, this description is subject to change and may be modified at any time, whether formally or informally.