Manager, Clinical Supply Chain

Centessa Pharmaceuticals, a wholly owned subsidiary of Eli Lilly and Company, is a clinical-stage company developing orexin receptor 2 (OX2R) agonists as a new class of medicines for the treatment of narcolepsy and potentially other sleep-wake disorders. Centessa’s lead investigational candidate – cleminorexton (formerly ORX750) – is being developed for narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia. Centessa's OX2R agonist portfolio includes additional clinical and preclinical-stage assets with potential utility across a broader range of neurological, neurodegenerative, and neuropsychiatric conditions. Headquartered in Boston, Massachusetts, Centessa was recognized as a Great Place to Work ® in 2026. Description of Role Centessa is seeking a Manager, Clinical Supply Chain to support end-to-end planning, execution, and maintenance of uninterrupted clinical supply — including investigational product (IP), comparators, and ancillary materials — across assigned clinical programs. This role ensures compliance with GxP requirements, study timelines, and budgets while partnering cross-functionally with Clinical Operations, CMC, Quality, Regulatory, Finance, and external vendors. Reporting to the Senior Director, Clinical Supply Chain, the individual will build strong relationships with internal teams and third-party suppliers to align objectives and support successful trial execution, with particular attention to clinical forecasts, inventory systems, and IRT tools. Key Responsibilities Clinical Supply Planning & Execution Contribute to the development and execution of clinical supply strategies for early- to mid-phase clinical trials (Phase 1–3 as applicable). Manage clinical supply plans, demand forecasts, and inventory strategies — including tracking through Interactive Response Technology (IRT) systems — in alignment with protocol requirements and enrollment projections. Support packaging, labeling, distribution, and resupply activities for investigational products and comparators. Ensure on-time delivery of clinical supplies to depots and clinical sites globally. Vendor & CDMO Management Partner with Quality, Clinical, CMC, and external CDMOs to develop, review, and approve clinical labels, and support CDMO packaging/labeling schedules to ensure supply availability. Interact regularly with third-party providers to manage the logistics and licenses required to ship materials from manufacturing to bulk storage facilities, courier depots, and investigator sites. Collaborate with CMC and QA to facilitate the document transfer required for IP/QP release by CDMOs. Quality & Compliance Support Monitor shelf-life and expiry dating, and coordinate retest/extension activities with the analytical team to ensure continuous supply. Manage the investigation, reporting, and communication of outcomes from temperature excursions and product complaints. Support product recovery activities pending investigation of IP from investigator sites, as needed. Cross-Functional Collaboration & Representation Communicate effectively across functional areas, applying a solid working knowledge of clinical supply chain processes. Author Pharmacy Manuals for clinical studies, as needed. Represent Supply Chain in Clinical and CMC Sub-Team meetings Qualifications Bachelor's degree in engineering or science required. 3–5 years of biotech/pharma industry experience in clinical supply chain, including international experience, required. Working knowledge of clinical supply chain processes and GMP/GDP requirements. Experience coordinating cross-functional project teams and external vendors. Strong organizational, analytical, decision-making, and interpersonal skills, with excellent attention to detail. Ability to work independently in a fast-paced, dynamic environment. Demonstrated ability to coordinate CDMO activities supporting clinical development of pharmaceutical products. Ability to thrive in a small-company culture and contribute to creating and implementing processes. Compensation The annual base salary range for this position is $90,000.00 to $215,000.00. Individual compensation within this range will be determined based on a variety of factors, including qualifications, skills, relevant experience, job knowledge an location. In addition to base pay, this role is eligible for a discretionary annual bonus. The Company also offers a comprehensive benefits package, which includes a 401(k) plan, company-sponsored medical, dental, vision, and life insurance, generous paid time off, and a health and wellness program. Work Location The Manager, Clinical Supply Chain role is a remote role based in the US, with occasional travel (up to 20%). POSITION: Full-Time, Exempt EEOC Statement: Centessa Pharmaceuticals, a wholly owned subdisary of Eli Lilly and Company believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion, or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. We will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Please note: We will not assign referral rights for any unsolicited resumes from recruitment agencies.