Principal Engineer, Microsoft 365 and Copilot Platforms

Job Description

General Summary:

The Principal Engineer, Microsoft 365 and Copilot Platforms serves as the execution-focused technical lead for Microsoft 365 Modern Work and enterprise AI capabilities. This role translates business demand into secure, governed, supportable outcomes.

The ideal candidate provides technical leadership across Microsoft Teams, SharePoint Online, OneDrive, Exchange with deep specialization in Microsoft Copilot, GitHub Copilot, Copilot Studio, agents, and AI governance. The role balances approximately 60% hands on work with 40% technical leadership.

Key Duties and Responsibilities:

• Own Technical Delivery: Lead Modern Work and AI initiatives, technical design, change control, implementation, working with our operations team.

• Lead business escalations, Critical incident management, root cause analysis and troubleshooting.

• Lead Microsoft Copilot and AI Enablement:
  • Copilot – SharePoint agents, Cowork
  • Copilot Studio - Power Automate, Power Apps
  • GitHub & GitHub Copilot

• Drive automation and continuous improvement across platforms.

• Act as the technical authority for the team by challenging solution design, coordinating working sessions, and engaging with stakeholders across the business and driving solutions

• Create and maintain environment documentations, SOP, KB articles for supported technologies
  

Knowledge and Skills:

• Broad Microsoft 365 Expertise: Principal- or Lead-level knowledge across Microsoft Teams, SharePoint Online, OneDrive, Exchange, Microsoft 365 governance, and related Entra ID, security, and compliance dependencies.
• Deep practical knowledge of Microsoft Copilot, Copilot Studio, Power Automate and Power Apps, agents, AI governance, and enterprise adoption controls – Agent 365.
• Demonstrated ability to convert broad objectives and business requirements into secure technical designs and completed delivery outcomes.
• Ability to balance business enablement, user experience and operational sustainability in a regulated enterprise environment.
• Experience leading complex technical escalations and coordinating execution across internal teams, control functions, vendors, and managed service providers.
• Excellent written and verbal communication skills, including the ability to explain technical decisions, risks, and recommendations to technical and non-technical audiences.
• Strong analytical and problem-solving skills, with comfort operating through ambiguity, incomplete information, shifting priorities, and multiple dependencies.

Education and Experience:

• Bachelor's degree (or equivalent degree) in Information Systems, Computer Science, Engineering, Business, or a related discipline, or equivalent professional experience.
• Extensive experience delivering and governing enterprise Microsoft 365 Modern Work capabilities, including ownership of complex technical delivery, operational escalations, and cross-functional implementation.
• Experience implementing Microsoft Copilot, Copilot Studio, enterprise agents, AI governance, or related AI productivity capabilities is strongly preferred.
• Experience working in a regulated enterprise environment and partnering with security, privacy, legal, compliance, identity, and operational teams is strongly preferred.
  

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range:

Disclosure Statement:

Flex Designation:

Flex Eligibility Status:

In this Hybrid-Eligible role, you can choose to be designated as:
1. Hybrid: work remotely up to two days per week; or select
2. On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

About Vertex

Help Us Achieve Our Mission

Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1.

Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 16 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visitwww.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X

We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.