Principal Scientist Formulation Development (m/w/d)

Who we are

ProBioGen is an international biotechnology company based in Berlin-Weißensee, specialising in the development and manufacture of biopharmaceuticals and vaccines. Every day, 300 employees contribute through their creative and meticulous work to advance new therapies and establish innovations worldwide.

Through our research, we support the development of effective and safe medicines – for example, for the treatment of cancer and other serious diseases.

As a partner in the Berlin Center for Gene and Cell Therapies (BC GCT), we are also actively shaping the future of gene and cell therapies and the expansion of state-of-the-art GMP production facilities in Berlin.

For our Formulation & Developability activities, we are looking for an experienced scientific expert who independently leads customer projects and works hand in hand with our laboratory team.

As Principal Scientist Formulation Development, you will take scientific ownership of customer-specific formulation, developability, and stability projects, from initial technical assessment to final recommendations. You will develop tailored, product- and phase-appropriate strategies that balance scientific requirements with material availability, timelines, manufacturability, and customer needs.

We have been growing steadily since 1994 - become one of tomorrow’s innovation drivers and apply now!

What you create

• Development of tailored formulation, developability, and stability strategies based on drug-substance characteristics, development phase, target product profile, material availability, timelines, and CMC-relevant risks
• Independent planning and leadership of customer-specific formulation, developability, and stability projects across different biopharmaceutical modalities, including antibodies, recombinant proteins, viral vectors, and vaccines
• Design and evaluation of formulation screening, optimization, high-concentration, stress, and stability studies, applying Design of Experiments (DoE), statistical modeling, and multivariate analysis to support data-driven development decisions
• Integration and interpretation of biophysical, chromatographic, electrophoretic, and particle-analysis data to establish comprehensive product understanding and derive formulation recommendations and risk mitigation strategies
• Early consideration of drug-product requirements and processability aspects, including target concentration, filtration, freeze/thaw stability, mechanical stress, storage conditions, and fill/finish requirements
• Scientific point of contact for international customers, with technical guidance throughout project assessment, study design, data evaluation, and final recommendations
• Close day-to-day collaboration with the laboratory team: joint planning of studies, scientific guidance during execution, troubleshooting, and evaluation of results
• Coordination with Analytics, Downstream Process Development, QC, Manufacturing, CMC, and Project Management to ensure successful project execution
• Evaluation of new methods and technologies, continuous improvement of our workflows, and scientific input for proposals and customer requests in cooperation with Business Development

What you bring along

• University degree in biochemistry, biophysics, biotechnology, pharmacy, chemistry, biology, or a related scientific discipline; a PhD is preferred
• Several years of relevant industry experience in formulation development, developability assessment, stability studies, or drug product development of biopharmaceuticals
• Strong understanding of the physicochemical principles governing biopharmaceutical stability, including degradation, aggregation, molecular interactions, solubility, and colloidal stability
• Proven experience in formulation development and the rational selection and application of buffers, excipients, stabilizers, and surfactants; experience with proteins, antibodies, viral vectors, or vaccines is particularly relevant
• Experience with DoE, statistical experimental design, and data-driven development approaches; knowledge of JMP or comparable software is an advantage
• Strong understanding of modern biophysical and stability-indicating analytical methods and the ability to translate complex analytical data into clear development decisions
• Experience in leading interdisciplinary scientific projects, interacting with customers and internal stakeholders, and communicating complex scientific topics effectively
• Excellent written and spoken English; good German language skills are an advantage

What you can expect

As a Principal Scientist you will work on scientifically challenging customer projects across different biopharmaceutical drug substances, modalities, and development phases.

You can expect a high degree of scientific independence, close collaboration with the laboratory, and short decision paths.

Whom to ask