Senior Director, GCS, Rare Endocrinology - CAH

Job Description

General Summary:

The Senior Director, Global Commercial Strategy (GCS), Rare Endocrinology - Congenital Adrenal Hyperplasia (CAH) will serve as the global commercial lead for atumelnant in CAH, spanning the adult and pediatric programs. Reporting to the Vice President, GCS - Rare Endocrinology, this leader will own the integrated commercial strategy for CAH and help translate the potential of atumelnant into a differentiated global commercialization plan.

Atumelnant joined the Vertex portfolio through the acquisition of Crinetics Pharmaceuticals and is in late-stage development for CAH. The Senior Director will lead commercial market assessment, shape pipeline development and evidence priorities, drive global launch preparation, and establish the lifecycle strategy across adult and pediatric CAH.

Key Duties & Responsibilities

• Serve as the global commercial lead for atumelnant in CAH across the adult and pediatric programs, establishing an integrated asset and indication strategy.
• Lead the commercial market assessment for CAH, including epidemiology, patient segmentation, unmet need, treatment patterns, patient and HCP journeys, competitive dynamics, access considerations, and global market potential.
• Develop and maintain the commercial strategy and target product profile for atumelnant in CAH, defining the patient populations, differentiation, value drivers, evidence requirements, and critical success factors required to win.
• Provide commercial leadership into adult and pediatric development plans, ensuring trial populations, endpoints, comparators, evidence generation, formulation, and label considerations support meaningful differentiation and commercialization objectives.
• Lead commercial development activities, including primary market research, forecasting, competitive intelligence, scenario planning, opportunity assessments, and investment recommendations.
• Develop the integrated global brand strategy for atumelnant in CAH, including positioning, strategic narrative, value proposition, indication sequencing, and adult and pediatric launch considerations.
• Lead global launch preparation, including launch strategy, market development, regional and country alignment, learning agenda, readiness milestones, cross-functional deliverables, and progress against critical success factors.
• Partner closely with regional and country Commercial teams to ensure the global strategy reflects market realities and can be translated into effective local launch plans.
• Own the global lifecycle management strategy for atumelnant in CAH, identifying opportunities to strengthen differentiation, expand patient impact, optimize the product profile, and maximize long-term value.
• Integrate commercial implications across adult and pediatric CAH while recognizing differences in patients, treaters, treatment settings, evidence needs, access, and launch execution.
• Partner across Development, Medical, Regulatory, Value & Access, HEOR, Analytics & Market Research, Finance, Manufacturing and Supply Chain, Patient Advocacy, and regional Commercial teams to deliver an aligned development and commercialization plan.
• Communicate clear, evidence-based recommendations to senior leaders and governance bodies, including key assumptions, trade-offs, risks, opportunities, and decisions required.
• Build strong external understanding through engagement with patients, caregivers, healthcare professionals, advocacy organizations, and other relevant stakeholders, consistent with applicable requirements.
• Lead and develop team members and external partners as the program advances, fostering strategic rigor, collaboration, accountability, and urgency.

Key Skills

• Demonstrated global launch-planning experience, including development of brand strategy, positioning, value proposition, market-development priorities, and launch-readiness plans.
• Experience developing lifecycle strategies that connect clinical development, evidence generation, label opportunities, formulation, and commercialization priorities.
• Experience working across adult and pediatric programs or managing materially different patient, customer, and evidence needs within one asset or disease area preferred.
• Experience in rare disease, endocrinology, specialty markets, or another complex market with concentrated customers and significant patient-identification challenges strongly preferred.
• Demonstrated ability to partner with Development, Medical, Regulatory, Market Access, HEOR, Finance, Manufacturing and Supply Chain, and regional Commercial teams in a global matrix.
• Exceptional strategic thinking, analytical rigor, business judgment, executive communication, and ability to translate complex clinical and market information into clear commercial recommendations.
• Proven ability to lead cross-functional work, influence without authority, develop talent, and deliver through periods of integration, uncertainty, and rapid change.

Education and Experience

• Minimum of a Bachelor’s degree in business, marketing, life sciences, healthcare, or a related field.
• Advanced degree such as an MBA, M.S., MPH, Pharm.D., Ph.D., M.D., or other relevant qualification preferred.
• Significant biopharmaceutical commercial experience, including global commercial strategy, new product planning, brand strategy, or marketing leadership.
• Demonstrated experience shaping pipeline or pre-launch assets and translating market insight into development strategy, target product profiles, evidence requirements, and investment decisions.
• Strong experience leading commercial opportunity assessments, market research, forecasting, competitive assessment, and scenario planning.

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range:

Disclosure Statement:

Flex Designation:

Flex Eligibility Status:

In this Hybrid-Eligible role, you can choose to be designated as:
1. Hybrid: work remotely up to two days per week; or select
2. On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

About Vertex

Help Us Achieve Our Mission

Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1.

Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 17 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visitwww.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X

We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.