Senior Director, Global HEOR, Hemoglobinopathies

Job Description

Vertex is seeking a talented and motivated individual to join its Global Health Economics & Outcomes Research (HEOR) group in Boston, MA. The Health Economics & Outcomes Research Senior Director will lead strategies and execution of evidence generation that optimize the value proposition of Vertex’s inline and pipeline assets for the Hemoglobinopathies (Heme) Disease Area through each stage of development, including launch and post-launch phases. This position reports to Global HEOR Cell and Gene Therapy Lead.

Key Responsibilities:

· Serves as the HEOR Heme Disease Area Lead

· Develops the HEOR strategy for assets in the Heme Disease Area from early development through product lifecycle

· Serves as HEOR lead to cross-functional and cross-regional teams to align strategic plans to stakeholder needs and represent the voice of HEOR and, at times, market access

· Ensures HEOR strategic plans are based on comprehensive review of internal and external stakeholder needs and appropriately aligned with clinical, medical and market access plans

· Oversees execution of HEOR core deliverables including evidence generation plans, outcomes research studies, models (cost-effective analysis and budget impact models), GVDs, etc., and leads execution of deliverables for Casgevy

· Supports the integration of HEOR evidence in health technology appraisal submissions for relevant assets

· Serves as HEOR lead to cross-functional teams up through Disease Strategy Team

· Collaborates closely with global commercial strategy, medical, clinical, and other functional teams to support and enhance access to marketed products across various regions

· Oversees the design and execution of HEOR studies and applies best practices for HEOR analyses, modeling and dissemination; ensures the highest quality standards for research and dissemination

· Responsibility for managing HEOR staff covering heme assets.

Knowledge and Skills:

· Extensive track record of publications in peer-reviewed journals demonstrating experience in patient reported outcomes, observational research, and health economic modeling

· Demonstrated capabilities to develop global strategic HEOR plans and execute studies

· Market Access experience, including direct experience in making submissions to relevant payers and interacting with them is strongly desired (US and EX-US)

· Comprehensive understanding of clinical development strategies and trial designs

· Strong communication skills, both verbal and written, including presentation skills to negotiate internally/externally often at higher levels

· Strong technical aptitude

· Broad and comprehensive understanding of the legal and regulatory environment of the pharmaceutical industry, demonstrated integrity on work-related compliance considerations and solid ethics

· Ability to manage complexity and ambiguity in a highly matrixed work environment

Education and Experience:

· Advanced degree (PhD, MD, Master's degree, MPH, or PharmD) in a relevant discipline.

· Typically requires 12 years of experience in health economics and outcomes research, or directly-related field and industry and 5 years of supervisory/management experience, or the equivalent combination of education and experience

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range:

$238,400 - $357,600

Disclosure Statement:

Flex Designation:

Hybrid-Eligible Or On-Site Eligible

Flex Eligibility Status:

In this Hybrid-Eligible role, you can choose to be designated as:
1. Hybrid: work remotely up to two days per week; or select
2. On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

About Vertex

Help Us Achieve Our Mission

Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1.

Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 16 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visitwww.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X

We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.