Senior Director, Head of Field Medical

Company Background

The mission of Neurogene is to treat devastating neurological diseases to improve the lives of patients and families impacted by these rare diseases. Neurogene is developing novel approaches and treatments to address the limitations of conventional gene therapy in central nervous system disorders. This includes selecting a delivery approach to maximize distribution to target tissues and designing products to maximize potency and purity for an optimized efficacy and safety profile.

The Company’s novel and proprietary EXACT transgene regulation platform technology allows for the delivery of therapeutic levels while limiting transgene toxicity associated with conventional gene therapy. Neurogene has constructed a state-of-the-art gene therapy manufacturing facility in Houston, Texas. CGMP production of NGN-401 was conducted in this facility and will support pivotal clinical development activities. This transformative work is driven by our highly collaborative people who come together each day to bring us closer to achieving our mission. As an employee of Neurogene, you will be part of building a culture that honors patient and caregiver mindsets and nurtures innovation, creative problem solving and a strong sense of purpose.

Position Overview –

· Remote - Field with 60% Travel

· Reports To The VP, Medical Affairs

Neurogene is seeking an experienced and highly collaborative Senior Director, Head of Field Medical to build and lead our U.S. Medical Science Liaison (MSL) organization.

This leader will be responsible for developing a high-performing field medical team and establishing the strategy, culture, capabilities, and operating model required to support Neurogene as we advance toward potential commercialization.

This is a critical leadership role within Medical Affairs. The Senior Director will translate Medical Affairs strategy into meaningful field execution, ensuring our MSL organization builds trusted scientific relationships with healthcare professionals, treatment centers, investigators, and other key external stakeholders while bringing high-quality insights back into the organization.

The ideal candidate is a proven field medical leader and team builder who understands that excellence in rare disease requires curiosity, credibility, strong judgment, exceptional people leadership, and an ability to operate effectively in a dynamic, rapidly evolving biotech environment, in addition to scientific expertise. The successful candidate will be a builder, coach and leader who can create an exceptional field organization from the ground up.

Experience in rare disease, pediatric neurology, genetic medicine, and/or gene therapy is highly valued, and we are equally interested in exceptional leaders who have demonstrated the ability to build and lead outstanding field medical organizations in complex specialty or rare disease environments.

This leader should be equally comfortable setting strategy and tactical planning, coaching an MSL after a customer interaction and contributing to broader Medical Affairs planning; challenging conventional thinking and listening carefully when the field tells us something we need to hear.

Most importantly, this leader will understand that in rare disease, every interaction matters. The quality of the team we build, the relationships we establish, and what we learn from the community will directly influence our ability to serve patients and families well.

Accountabilities and Responsibilities

Build and Lead a World-Class Field Medical Team

• Recruit, onboard, develop, coach, and retain a high-performing team of MSLs capable of operating with scientific credibility, independence, and sound judgment.

• Establish a strong field medical culture grounded in scientific excellence, patient focus, accountability, collaboration, curiosity, and continuous learning.

• Create clear expectations for performance and provide consistent coaching, feedback, development, and career mentorship.

• Spend meaningful time in the field alongside MSLs to understand customers, assess effectiveness, coach performance, and remain connected to the evolving external environment.

• Build the capabilities and infrastructure necessary for the field organization to scale as Neurogene progresses toward potential launch.

• Serve as a hands-on leader and coach during the build and transition period, stepping directly into field, scientific, and stakeholder-facing activities as needed while the organization scales.

Field Medical Strategy & Execution

• Partner with Medical Affairs leadership to develop and execute the U.S. field medical strategy aligned with broader medical, clinical development, and organizational priorities.

• Translate Medical Affairs objectives into clear, actionable field plans and ensure consistent, high-quality execution across the MSL organization.

• Establish the field medical operating model, including territory and account planning, stakeholder prioritization, engagement standards, congress coverage, insight generation, and appropriate performance measures.

• Continuously evaluate field priorities and resource deployment as the clinical, competitive, and treatment landscape evolves.

• Ensure the team maintains deep scientific expertise in the disease state, clinical program, treatment landscape, emerging science, and competitive environment.

External Scientific Engagement

• Guide the development of meaningful, long-term scientific relationships with key opinion leaders, investigators, healthcare professionals, treatment centers, and other relevant stakeholders.

• Ensure high-quality, balanced, and scientifically rigorous peer-to-peer exchange.

• Support engagement with emerging experts and multidisciplinary stakeholders involved in the diagnosis, management, and treatment of patients with rare neurologic diseases.

• Provide leadership and coordination for field medical activities at major scientific congresses, investigator meetings, and other external engagements.

• Maintain personal relationships with select national and strategic thought leaders as appropriate.

• Partner with the broader Medical Affairs organization to support external scientific communications and stakeholder engagement, ensuring a consistent scientific narrative across audiences and channels.

• Support scientifically rigorous, compliant engagement with payer and healthcare system decision makers, recognizing the distinct evidence needs associated with one-time, high-complexity gene therapies.

Insights & Organizational Learning

• Build a disciplined approach to identifying, synthesizing, communicating, and acting upon insights generated through field engagement.

• Ensure insights go beyond activity reporting and meaningfully inform Medical Affairs strategy, evidence generation, clinical development, education, stakeholder engagement, and launch planning.

• Identify emerging scientific, clinical, competitive, and operational trends and ensure important information is communicated rapidly and effectively across the organization.

• Partner with Medical Affairs leadership to continually refine field strategy based on external learning.

Field Medical Enablement & Resource Development

• Collaborate with internal medical affairs teams to drive the development of scientific resources, tools, and training that equip MSLs for meaningful, high-quality scientific engagement.

• Ensure field-facing resources and platforms evolve alongside the clinical program, emerging data, and the external environment.

Cross-Functional Leadership

• Serve as a trusted partner across Medical Affairs, Clinical Development, Regulatory, Commercial, Market Access, Patient Advocacy, and other functions while maintaining appropriate Medical Affairs independence and compliance.

• Represent the field medical perspective in cross-functional planning and decision-making.

• Help the organization understand the evolving needs of treatment centers and healthcare professionals as Neurogene prepares for the potential introduction of a novel gene therapy.

• Play a critical role in supporting treatment site readiness and implementation, partnering with cross-functional teams to ensure centers are scientifically and operationally prepared to evaluate and adopt a novel gene therapy.

• Ensure the MSL team is structured and deployed to meet the needs of treating centers, referral networks, and the broader care community, adjusting coverage as the treatment landscape evolves.

• Contribute broadly as a leader within a growing organization, supporting priorities across the wider Medical Affairs organization where responsibilities may extend beyond traditional functional boundaries.

Compliance & Operational Excellence

• Ensure all field medical activities are conducted in accordance with applicable laws, regulations, industry standards, and Neurogene policies.

• Establish appropriate objectives, metrics, systems, processes, and operating rhythms to assess effectiveness and continually improve field medical execution.

• Manage field medical resources and budgets responsibly.

• Partner with Medical Operations and other functions to ensure systems, training, processes, and tools effectively support the field organization.

Minimum Requirements

Education

• Advanced scientific or clinical degree (PharmD, PhD, MD/DO, PA, NP, MPH)

Experience

• 10+ years of biopharmaceutical industry experience, including preferred minimum 6 years in Medical Affairs with significant field-based experience including leading field medical teams, (hiring, developing, and managing MSL teams)

• Experience leading field medical through at least one product launch strongly preferred

• Strong understanding of field medical strategy, scientific exchange, insight generation, KOL engagement, and Medical Affairs compliance.

• Experience in rare disease, neurology, and/or pediatric disease, ideally within gene therapy, genetic medicine, or another advanced therapeutic modality

• Pre-launch, launch, and/or early commercialization experience supporting therapies that require specialized treatment centers, multidisciplinary coordination, extensive site preparation, and payer or access-related scientific engagement

• Strong scientific acumen and the ability to rapidly develop expertise in complex diseases and novel therapeutic modalities.

• Excellent communication, interpersonal, and leadership skills with demonstrated ability to influence across functions and levels of an organization.

• Comfort operating as both a leader and an individual contributor during periods of transition and growth.

• Ability to thrive in a fast-moving biotech environment characterized by evolving priorities, ambiguity, and significant individual accountability.

• Willingness to travel extensively to support field engagement, team development, scientific meetings, and other business needs.

Knowledge, Skills and Attributes

• Ability to understand and articulate complex medical and scientific information to internal and external stakeholders and tailor information to specific audiences.

• Outstanding presentation, written, and oral communication skills.

• Ability to identify, cultivate, and maintain key external relationships with key stakeholders.

• Ability to manage competing priorities and projects.

• Ability to prioritize and manage expectations while analyzing complex issues.

• Thrive in a fast-paced, innovative environment while remaining agile and adaptive.

• Flexibility to learn new skills, adapt within a fast-paced, dynamic environment, work without having the complete picture, and handle uncertainty.

• Ability to maintain the highest degree of confidentiality and integrity; uphold the company’s high ethics and professionalism.

• Adhere to corporate compliance policies in all activities, including those related to clinical trials, scientific interactions with internal and external groups, and unsolicited requests for medical/scientific information.

• Continuous strong focus on meeting or exceeding expectations in executing deliverables, performance and results.

• Ability to track and measure performance against defined metrics.

• Self-starter with high degree of energy, independence, initiative, and self-motivation, as illustrated by the ability to instill a sense of pace and urgency into the team.

• Someone who moves fast and decisively in a balanced manner, with a passion for the growing company.

• Passionate, collaborative, creative, willing to take prudent risks, and motivated by the creation of a company focused on transformative treatments for patients and their families.

This job description has been developed based upon the expected and current duties, responsibilities and requirements for the position. Because job requirements evolve with the changing needs of Neurogene’s business, this description is subject to change and may be modified at any time, whether formally or informally.

Neurogene is an Equal Opportunity Employer and will assess all applicants based on their qualifications for the job, without regard to race, color, sex, religion, national origin, age, disability, sexual orientation, gender identity, protected veteran, disability status or any other characteristics protected by applicable federal, state or local law.