Senior Scientist, Potency Assay Development
- Hiring from
- Netherlands
- Work type
- Hybrid
- Posted
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About VectorY
VectorY is a fast-growing biotech company developing long-lasting therapies for neurodegenerative diseases, based at Amsterdam Science Park. We combine antibody engineering with innovative delivery technology to pursue new possibilities where medical need is high. With approximately 80 professionals across Amsterdam, Europe and the US, we are building momentum and scaling our organisation thoughtfully. At VectorY, innovation and collaboration are not just values. They are how we achieve our ambition. We believe the best ideas emerge when people challenge each other openly, work across boundaries, and stay focused on what is right for the organisation. We embrace diversity while striving to function as one cohesive, mission-driven team. As our lead programme advances through late-stage clinical development, so does the need for a robust, regulatory-compliant potency strategy.
The Role
As Senior Scientist, Potency Assay Development, you will lead the development, validation, transfer and lifecycle management of the potency assays that support release and stability testing of our clinical AAV-based product, which expresses a therapeutic antibody fragment for the treatment of neurodegenerative diseases. You will design and implement a scientifically sound potency strategy that links AAV transduction, transgene expression and the biological function of the expressed antibody fragment to its clinical mechanism of action. As the analytical subject matter expert for product potency, you will work closely with Research, Quality, Regulatory Affairs and Manufacturing, and represent VectorY towards external GMP laboratories and Health Authorities.
Who You Are
You combine deep expertise in AAV vector biology and cell-based bioassays with a strong understanding of late-stage CMC development and regulatory expectations. You are hands-on and pragmatic: you find workable solutions instead of perfect ones on paper. You design experiments with statistical rigour, translate complex science into clear documentation and are comfortable defending your scientific choices with regulators.
This role is a great fit for you if...
You enjoy connecting biology to regulatory strategy and like to get things done. You are just as comfortable working through the challenges of a complex cell-based potency assay as you are writing a validation protocol or contributing to a regulatory submission. If you are looking for a role where your potency strategy directly shapes how a late-stage therapy reaches patients, this could be an excellent next step.
VectorY is a fast-growing biotech company developing long-lasting therapies for neurodegenerative diseases, based at Amsterdam Science Park. We combine antibody engineering with innovative delivery technology to pursue new possibilities where medical need is high. With approximately 80 professionals across Amsterdam, Europe and the US, we are building momentum and scaling our organisation thoughtfully. At VectorY, innovation and collaboration are not just values. They are how we achieve our ambition. We believe the best ideas emerge when people challenge each other openly, work across boundaries, and stay focused on what is right for the organisation. We embrace diversity while striving to function as one cohesive, mission-driven team. As our lead programme advances through late-stage clinical development, so does the need for a robust, regulatory-compliant potency strategy.
The Role
As Senior Scientist, Potency Assay Development, you will lead the development, validation, transfer and lifecycle management of the potency assays that support release and stability testing of our clinical AAV-based product, which expresses a therapeutic antibody fragment for the treatment of neurodegenerative diseases. You will design and implement a scientifically sound potency strategy that links AAV transduction, transgene expression and the biological function of the expressed antibody fragment to its clinical mechanism of action. As the analytical subject matter expert for product potency, you will work closely with Research, Quality, Regulatory Affairs and Manufacturing, and represent VectorY towards external GMP laboratories and Health Authorities.
Who You Are
You combine deep expertise in AAV vector biology and cell-based bioassays with a strong understanding of late-stage CMC development and regulatory expectations. You are hands-on and pragmatic: you find workable solutions instead of perfect ones on paper. You design experiments with statistical rigour, translate complex science into clear documentation and are comfortable defending your scientific choices with regulators.
This role is a great fit for you if...
You enjoy connecting biology to regulatory strategy and like to get things done. You are just as comfortable working through the challenges of a complex cell-based potency assay as you are writing a validation protocol or contributing to a regulatory submission. If you are looking for a role where your potency strategy directly shapes how a late-stage therapy reaches patients, this could be an excellent next step.
What You'll Do
- Serve as analytical subject matter expert for product potency throughout late-stage clinical development
- Develop a potency framework that demonstrates AAV cellular transduction, expression of the antibody fragment and functional biological activity of the expressed therapeutic protein
- Ensure potency methods reflect regulatory expectations for mechanism-of-action-based testing
- Develop and optimise assays across relevant levels of biological activity, from infectivity and transduction assays reflecting the biological activity of the expressed therapeutic protein
- Establish scientifically justified acceptance criteria
- Lead assay qualification and validation activities in line with applicable guidelines
- Author validation protocols and reports, comparability assessments and method lifecycle plans
- Transfer validated potency assays to external GMP QC laboratories
- Author and review potency sections within IND amendments, IMPDs, BLA Module 3 submissions and MAA dossiers
- Lead discussions on potency strategy with Research, Quality, Regulatory Affairs, Manufacturing and Health Authorities, and defend assay design and validation strategies during regulatory interactions
What You Bring
- A PhD in Molecular Biology, Neuroscience, Cell Biology, Biochemistry, Immunology, Pharmaceutical Sciences, Virology, Gene Therapy or a related field
- 5+ years of industry experience
- A proven track record in developing cell-based potency assays for genetic medicines or other complex biological products; direct experience with AAV-based products is strongly preferred
- Strong expertise in cell-based bioassays and a deep understanding of bioanalytical and analytical method validation
- Experience supporting late-stage clinical development programmes (Phase II/III)
- Experience with CNS-focused therapeutics or neurodegenerative disease mechanisms is highly desirable
- Strong skills in experimental design, statistical analysis and technical writing
- Regulatory awareness and the ability to influence cross-functionally
What We Offer
Our selection process
Our process consists of two online interviews followed by an on-site interview at Amsterdam Science Park, for which you will prepare a short scientific presentation.
We will start reviewing applications and inviting candidates for interviews from 19 November 2026. Applications received after this date are still welcome and will be considered until the position is filled.
- A senior scientific role with ownership of the potency strategy for a late-stage clinical programme
- The opportunity to shape analytical development at an exciting stage of VectorY growth
- Close collaboration with Research, Quality, Regulatory Affairs and Manufacturing
- A collaborative and international working environment
- Competitive salary and benefits package
- 30 holidays on a full-time basis
- Hybrid working model with office days at Amsterdam Science Park
Our selection process
Our process consists of two online interviews followed by an on-site interview at Amsterdam Science Park, for which you will prepare a short scientific presentation.
We will start reviewing applications and inviting candidates for interviews from 19 November 2026. Applications received after this date are still welcome and will be considered until the position is filled.
