Vice President, Marketing

Company Background

The mission of Neurogene is to treat devastating neurological diseases to improve the lives of patients and families impacted by these rare diseases. Neurogene is developing novel approaches and treatments to address the limitations of conventional gene therapy in central nervous system disorders. This includes selecting a delivery approach to maximize distribution to target tissues and designing products to maximize potency and purity for an optimized efficacy and safety profile. The Company’s novel and proprietary EXACT transgene regulation platform technology allows for the delivery of therapeutic levels while limiting transgene toxicity associated with conventional gene therapy.

Neurogene has constructed a state-of-the-art gene therapy manufacturing facility in Houston, Texas. CGMP production of NGN-401 was conducted in this facility and will support pivotal clinical development activities. This transformative work is driven by our highly collaborative people who come together each day to bring us closer to achieving our mission. As an employee of Neurogene, you will be part of building a culture that honors patient and caregiver mindsets and nurtures innovation, creative problem solving and a strong sense of purpose.

Position Overview - Reports To: Chief Commercial Officer – Remote

Neurogene is seeking an accomplished, strategic, and hands-on Vice President, Marketing to lead the development and execution of our commercial marketing strategy as we prepare for the potential first launch of NGN-401, our investigational gene therapy for Rett syndrome. This is a unique opportunity to play a pivotal role in bringing an innovative therapy toward commercialization while establishing the marketing capabilities and strategic foundation to support Neurogene's growing pipeline.

Reporting to the Chief Commercial Officer, the Vice President, Marketing will be responsible for building a differentiated brand, leading integrated prelaunch market-shaping initiatives, and driving comprehensive marketing launch readiness. The successful candidate will combine deep rare disease commercialization experience, scientific fluency, exceptional brand-building capabilities, and strong commercial judgment.

We are seeking an established marketing executive who is equally comfortable shaping strategy and rolling up their sleeves to execute. This leader will thrive in an entrepreneurial environment, serve as a trusted commercial thought partner, and collaborate closely across functions to support a successful launch and long-term organizational growth.

Accountabilities and Responsibilities

Brand Strategy and Commercial Marketing Leadership

• Lead the development and execution of an integrated U.S. marketing strategy for NGN-401, encompassing prelaunch preparation, brand development, launch execution, and postlaunch optimization.

• Personally drive the development of a differentiated brand platform, including positioning, messaging architecture, brand identity, narrative development, and creative strategy.

• Translate complex clinical and scientific information into compelling, credible, and evidence-based communications for healthcare professionals, patients, and caregivers.

• Anticipate evolving market dynamics, competitive developments, and stakeholder needs to inform positioning, differentiation, and marketing priorities.

• Lead comprehensive HCP marketing strategies, including audience segmentation, promotional content, digital engagement, and integrated campaigns.

• Develop scalable marketing capabilities and contribute to early commercial assessments and positioning strategies for future Neurogene programs.

Prelaunch Market Shaping and Launch Readiness

• Lead the integrated commercial market-shaping strategy, including disease-state education, stakeholder segmentation, treatment-journey insights, and prelaunch engagement planning.

• Partner closely with Market Development, Medical Affairs, Patient Advocacy, and Customer Engagement to align market-shaping priorities and coordinate cross-functional initiatives.

• Establish and execute comprehensive marketing launch plans, ensuring readiness across brand strategy, campaigns, promotional materials, agencies, budgets, and key milestones.

• Serve as a key leader in integrated commercial launch planning, working with the CCO and functional leaders to align priorities, manage dependencies, identify execution risks, and assess readiness.

• Ensure appropriate regulatory and compliance considerations are incorporated into all pre-approval and post-approval marketing activities.

Patient, Caregiver, and HCP Engagement

• Own the strategic development and execution of patient and caregiver marketing initiatives, grounded in a deep understanding of the rare disease experience and treatment decision-making journey.

• Translate authentic patient and caregiver insights into empathetic, accessible, and effective educational and promotional strategies.

• Partner with Patient Advocacy and Patient Services to ensure coordinated, patient-centered approaches while maintaining clear functional accountability.

• Develop HCP communications and marketing programs that support broader commercial objectives, collaborating with Market Development and Customer Engagement while preserving their ownership of external stakeholder relationships, referral pathway development, and treatment-center engagement strategies.

• Maintain a strong external perspective through appropriate engagement with healthcare professionals, patient and caregiver communities, advisory boards, and industry stakeholders, in coordination with relevant cross-functional partners.

Omnichannel Marketing and Marketing Effectiveness

• Lead the development of an integrated omnichannel marketing strategy, including audience segmentation, stakeholder journeys, content strategy, channel planning, and performance measurement.

• Partner with Market Development, Customer Engagement, Commercial Operations, and external agencies to coordinate execution across relevant audiences and channels.

• Establish meaningful prelaunch and postlaunch marketing performance indicators, including awareness, knowledge, engagement, campaign effectiveness, and brand performance.

• Leverage market research, competitive intelligence, customer insights, and commercial analytics to guide strategic decisions and optimize marketing investments.

• Establish research priorities and translate insights into actionable marketing strategies, partnering with or directly overseeing research and analytics capabilities as the organization evolves.

Marketing Operations and Financial Stewardship

• Own the development and disciplined management of marketing budgets, resource allocation, agency partnerships, and marketing investments.

• Lead agency selection, strategic direction, performance management, and execution oversight, ensuring high-quality deliverables, efficient resource utilization, and accountability for results.

• Demonstrate strong commercial and financial acumen, contributing to market assessments, business planning, and commercial forecasting through an understanding of rare disease market dynamics, patient identification, and treatment adoption.

• Collaborate with Commercial Operations, Finance, Regulatory, Legal, and Medical Affairs to support efficient execution, promotional review, and compliant marketing practices.

• Build and scale marketing capabilities and resources in alignment with launch priorities and the evolving needs of the organization.

Strategic Leadership and Cross-Functional Collaboration

• Serve as a trusted strategic partner to the Chief Commercial Officer and broader leadership team, bringingindependent thinking, sound commercial judgment, and actionable recommendations.

• Influence cross-functional strategic decisions through clear communication, scientific understanding, market insights, and thoughtful challenge of assumptions.

• Foster strong partnerships across Medical Affairs, Market Development, Customer Engagement, Patient Advocacy, Market Access, Commercial Operations, and other key functions.

• Demonstrate a collaborative, entrepreneurial, and results-oriented leadership style, balancing strategic vision with hands-on execution.

• Contribute to a culture of accountability, intellectual curiosity, innovation, trust, and continuous improvement.

• Provide strategic input into broader pipeline and international commercialization initiatives as appropriate.

Minimum Requirements

Education

• Bachelor's degree in business, marketing, life sciences, or a related discipline; advanced

degree preferred.

Experience Required:

• Minimum of 15 years of progressive pharmaceutical or biotechnology industry

experience, including significant marketing leadership responsibility.

• Demonstrated success leading at least one rare disease product launch, with

meaningful accountability for brand strategy, market preparation, and launch

execution.

• Extensive experience developing differentiated brand strategies, positioning,

messaging, integrated marketing campaigns, and commercial launch plans.

• Proven experience leading marketing activities through prelaunch planning,

promotional development, medical/legal/regulatory review, and branded

commercialization.

• Experience developing omnichannel marketing strategies and leveraging market

research, competitive intelligence, and analytics to inform commercial decisions.

Preferred Experience:

• Prior Vice President-level marketing leadership experience.

• Experience commercializing cell and gene therapies or other innovative, high complexity

treatments.

• Experience supporting a first commercial launch within an emerging biotechnology

company.

• Experience in pediatric rare diseases and caregiver-driven treatment decisions.

• Familiarity with complex institutional treatment environments and specialized

healthcare delivery models.

• Experience establishing marketing capabilities and scaling teams or resources in a

growing biotechnology organization.

• Experience contributing to broader pipeline strategy or international commercialization

planning.

Knowledge, Skills, and Attributes

• Scientifically credible. Understands complex clinical evidence, interprets data, and

translates scientific concepts into meaningful, accurate, and differentiated

communications and effective commercial strategies.

• Patient- and caregiver-centered. Brings genuine understanding of rare disease

communities, patient and caregiver experiences, and complex treatment decisionmaking,

and integrates their perspectives into commercial decision-making.

• Strategic and commercially astute. Connects scientific innovation, market dynamics,

stakeholder needs, and commercial opportunity to develop compelling strategies and

commercial plans.

• Financial and business acumen. Demonstrated marketing budget accountability and

agency management, with a disciplined approach to prioritizing investments.

• Accountable and results-driven. Takes ownership of outcomes, maintains a continuous

strong focus on meeting or exceeding expectations, and tracks and measures

performance against defined metrics, using insights to guide decisions.

• Hands-on and execution-oriented. Personally drives critical work, challenges agency

thinking, and delivers results without relying on a large organizational infrastructure.

• Executive presence and cross-functional influence. Communicates effectively, builds

trust, works across functions, and advances shared objectives.

• Entrepreneurial and adaptable. Navigates ambiguity and operates effectively in a

dynamic, evolving organization without unnecessary hierarchy.

• Self-starter with a sense of urgency. Brings a high degree of energy, independence,

initiative, and self-motivation, instills pace and urgency in the team, and moves fast

and decisively in a balanced manner.

• Confident and intellectually curious. Brings independent perspectives, challenges

assumptions constructively, and continuously seeks better approaches.

• Passionate and mission-driven. Passionate about the growing company, creative,

willing to take prudent risks, and motivated by the creation of a company focused on

transformative treatments for patients and their families.

This job description has been developed based upon the expected and current duties, responsibilities, and requirements for the position. Because job requirements evolve with the changing needs of Neurogene’s business, this description is subject to change and may be modified at any time, whether formally or informally.

Neurogene is an Equal Opportunity Employer and will assess all applicants based on their qualifications for the job, without regard to race, color, sex, religion, national origin, age, disability, sexual orientation, gender identity, protected veteran, disability status or any other characteristics protected by applicable federal, state or local law.