Scientist, Organic Chemistry — Night Shift

We are an intensely mission-driven team in San Francisco, with members from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber.

We value speed, rigor, curiosity, and a strong work ethic. We look for ambitious, high-integrity people who bring clarity to open-ended problems, take ownership, and follow through.

Chemists and scientists can help shape our therapeutic programs. One of our chemists discovered the target for our next exercise mimetic and designed many of its key compounds.

Human–AI collaboration is central to our work: scientists use AI alongside their own judgment to generate ideas, design experiments, and move programs forward faster.

You’ll get direct feedback from scientific and company decision-makers, with room to become dramatically better and own increasingly important problems. We believe excellent work deserves meaningful reward, ownership, and trust. Responsibility grows with contribution, regardless of title.

This is a night shift role, with two options:

• Evening: about 6pm–2:30am

• Overnight: 2am–10am

Night owls will be mission-critical to scaling our semi-autonomous lab.

About the Role

You will run organic-chemistry workflows on a dedicated night-shift schedule so compounds are ready for characterization, biological testing, or handoff the next day. You will execute solution- and solid-phase chemistry, solve experimental problems independently, maintain complete records, and give the day team a clear account of every result and open issue.

Responsibilities

• Execute overnight synthesis workflows, including route planning, reaction setup, workup, purification, characterization, and sample preparation.

• Run and troubleshoot organic reactions involving functional-group transformations, coupling chemistry, protecting-group strategies, late-stage diversification, and parallel synthesis.

• Use solution-phase and solid-phase methods where appropriate, including cleavage, deprotection, crude analysis, purification, and final quality control.

• Resolve overnight issues involving low conversion, poor selectivity, side products, decomposition, solubility, purification, recovery, and instrument downtime.

• Purify and characterize compounds using analytical HPLC, prep HPLC, LC-MS, NMR, flash chromatography, SFC, and related methods as appropriate.

• Prepare compounds for in vitro and in vivo testing and maintain accurate experimental and batch-level quality-control records.

• Provide clear morning handoffs covering completed work, results, failures, sample locations, risks, and follow-up actions.

Ideal Qualifications

• Able and willing to work the designated night-shift schedule reliably and operate independently when needed.

• Hands-on synthetic chemistry experience and strong experimental discipline.

• Interest in owning overnight chemistry from reaction execution through purification, characterization, documentation, and sample handoff.

• A creative, fast, rigorous, and safety-conscious approach to laboratory problem-solving.

• Sound judgment when a reaction fails, an instrument is down, data look unusual, or the usual day-team contact is unavailable.

• The ability to maintain excellent records and create clean, useful handoffs across night and day teams.

Pay & Benefits

• Compensation and equity will depend on the skills, experience, and scope of impact you bring. We are open to a conversation based on the scope and impact you could bring.

• $500+ monthly wellness budget for training, supplements, coaching, recovery, or other tools that help you perform at your best.

• Healthcare: We offer a broad range of medical, dental, and vision coverage options, with Capable covering 100% of the base policy.

• You will also have access to HSA, FSA, and 401K plans.

• Healthy vegetarian dinners with the team are provided daily.

• We support visa sponsorship where appropriate, including O-1, H-1B, J-1, TN, and other employment-based pathways. Our team is already international, with members from Canada, Pakistan, Germany, Austria, Switzerland, China, India, and the United States.

Application Process

Our process is fast, transparent, and personal. We care about getting to know the person behind the application.

• Initial application

• First phone screen

• Second phone screen

• In-person on site work trial in San Francisco: designed to give both sides a realistic sense of working together. Get to know the founding team!

Apply Today

Curious but not sure? Apply anyway. It takes 5 minutes, and you do not need to be actively job searching to start a conversation.

Some of the best people do not map perfectly to a job description. If this sounds like a place where you could do important work, we would like to hear from you.

And if someone exceptional comes to mind, send them our way here. We read every referral carefully, and if your referral joins Capable, we’ll send you a thank-you bonus.

Equal Opportunity

Capable is an Equal Opportunity Employer; employment with Capable is governed on the basis of merit, competence and qualifications and will not be influenced in any manner by race, color, religion, gender, national origin/ethnicity, veteran status, disability status, age, sexual orientation, gender identity, marital status, mental or physical disability or any other legally protected status.